Probiotic composition and preparation for treating rapid eye movement sleep behavior disorder in patients with Parkinson disease and applications of probiotic composition and preparation

A probiotic preparation, a technology for Parkinson's disease, used in drug combinations, medical preparations containing active ingredients, nervous system diseases, etc. The effect of improving motor symptoms, good clinical application prospects and market prospects

Active Publication Date: 2020-06-19
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, some patients may experience RBD aggravation, or even hallucinations, etc. Sleep disorders directly affect ...

Method used

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  • Probiotic composition and preparation for treating rapid eye movement sleep behavior disorder in patients with Parkinson disease and applications of probiotic composition and preparation
  • Probiotic composition and preparation for treating rapid eye movement sleep behavior disorder in patients with Parkinson disease and applications of probiotic composition and preparation
  • Probiotic composition and preparation for treating rapid eye movement sleep behavior disorder in patients with Parkinson disease and applications of probiotic composition and preparation

Examples

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preparation example Construction

[0054] The preparation method of the freeze-dried bacterial powder is a conventional technique, and known techniques such as CN110367543A, CN110720638A, and CN102356912B can be referred to.

[0055] The probiotic composition, preparation method and colony standard of the present invention are in compliance with the third part of the 2010 edition of the Chinese Pharmacopoeia and the 2000 edition of the Chinese Biological Products Regulations.

[0056] The CFU / g in the present invention is the number of colonies contained in each g of the test sample, and CFU is a colony forming unit. The CFU / g described in the following examples generally refers to "equal to" or "not lower than". The number of viable bacteria in the medium is "not less than".

[0057] The following examples of the present invention prepare probiotic capsules, and the equipment used includes a three-dimensional motion mixer (SBH series of Jiangsu Baobao Group Co., Ltd.), a capsule filling machine (Beijing Guowe...

Embodiment 1

[0058] The preparation of embodiment 1 probiotic preparation of the present invention

[0059] (1) Mix the dry freeze-dried bacterial powder of Bacillus licheniformis live bacteria, Bifidobacterium longum, Lactobacillus acidophilus and Enterococcus faecalis with auxiliary materials to obtain a uniform mixture; in this embodiment, the auxiliary materials are pregelatinized starch and lactose;

[0060] (2) subpackage the mixture obtained in step (1) into capsules to make capsules, the capsules of the capsules are enteric-coated capsules, and each capsule contains 250 mg of mixed bacteria powder.

[0061] Each capsule contains no less than: Bacillus licheniformis 10×10 8 CFU / g, Bifidobacterium longum 4.0×10 8 CFU / g, Lactobacillus acidophilus 1.0×10 8 CFU / g, Enterococcus faecalis 0.5×10 8 CFU / g.

[0062] After meeting the above-mentioned number of live bacteria, the auxiliary material is the balance, and the mass ratio of pregelatinized starch and lactose is 1:1. The prepara...

Embodiment 2

[0062] After meeting the above-mentioned number of live bacteria, the auxiliary material is the balance, and the mass ratio of pregelatinized starch and lactose is 1:1. The preparation of embodiment 2 probiotic preparations of the present invention

[0063] (1) Mix the dry freeze-dried bacterial powder of Bacillus licheniformis live bacteria, Bifidobacterium longum, Lactobacillus acidophilus and Enterococcus faecalis with auxiliary materials to obtain a uniform mixture; in this embodiment, the auxiliary materials are pregelatinized starch and lactose;

[0064] (2) subpackage the mixture obtained in step (1) into capsules to make capsules, the capsules of the capsules are enteric-coated capsules, and each capsule contains 250 mg of mixed bacteria powder.

[0065] Each capsule contains no less than: Bacillus licheniformis 10×10 9 CFU / g, Bifidobacterium longum 4.0×10 9 CFU / g, Lactobacillus acidophilus 1.0×10 9 CFU / g, Enterococcus faecalis 0.5×10 9 CFU / g.

[0066] After meet...

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Abstract

The invention discloses a probiotic composition for treating rapid eye movement sleep behavior disorder (RBD) in patients with Parkinson disease (PD). The composition is prepared from bacillus licheniformis, bifidobacterium longum, lactobacillus acidophilus, enterococcus faecalis and pharmaceutically acceptable auxiliary materials, wherein the number of live bacteria of the bacillus licheniformisis not less than 10.0x10<8> CFU/g; the number of live bacteria of the bifidobacterium longum is not less than 4.0x10<8> CFU/g; the number of live bacteria of the lactobacillus acidophilus is not lessthan 1.0x10<8> CFU/g; and the number of live bacteria of the enterococcus faecalis is not less than 0.5x10<8> CFU/g. In the probiotic composition, the components have a synergistic effect, the RBD symptom in the PD patients can be effectively treated and improved, and the treatment effect is good in continuity and excellent in stability; the composition can effectively improve the motor symptom ofthe PD patients while having a treatment effect on the RBD symptom of the PD patients, and solves the problem that current drugs cannot treat the motor symptom and non-motor symptoms of the PD patients at the same time; and the composition can effectively reduce the dosage of levodopa in the PD patients and prevent the patients from generating resistance to levodopa prematurely, and has a betterprotection effect on the patients.

Description

technical field [0001] The invention relates to a probiotic composition, in particular to a probiotic composition for treating rapid eye movement sleep behavior disorder and movement disorder in patients with Parkinson's disease and a preparation prepared from the composition. Background technique [0002] Parkinson's disease (PD for short) is a disease characterized by slow movement, resting tremor, and muscle rigidity, and its main pathological features are the loss of dopaminergic neurons in the substantia nigra of the midbrain and the residual Lewy bodies (mainly misfolded α-synuclein) form. In addition to the above motor symptoms, the clinical manifestations also include many non-motor symptoms, such as constipation, rapid eye movement sleep behavior disorder (RBD for short), hyposmia, cognitive impairment, depression and so on. [0003] PD is a chronic progressive disease. At present, there are mainly the following categories of drugs for the treatment of motor sympt...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P25/16A61P25/20A61K35/741A61K35/742A61K35/745
CPCA61K35/747A61K35/745A61K35/742A61K35/741A61P25/16A61P25/20A61K2300/00A61P25/14
Inventor 脱厚珍杜艺彤许晓娇李悦高丹高婷薛云张铭凯
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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