Artificial aqueous humor micro-drainage tube with drug sustained release function and preparation method of artificial aqueous humor micro-drainage tube

Abstract

The invention relates to the technical field of medical biological materials for ophthalmology, and provides an artificial aqueous humor micro-drainage tube with a drug sustained release function and a preparation method thereof.The artificial aqueous humor micro-drainage tube with the drug sustained release function is characterized in that a drug-loaded micro-drainage tube substrate is prepared from a biocompatible high polymer material, and pore forming is conducted on the drug-loaded micro-drainage tube substrate in combination with CAD / CAM aided design and a femtosecond laser technology; meanwhile, a heparin coating is covalently grafted on the surface of the substrate through a grafting coupling technology, the device is suitable for minimally invasive implantation, good in biocompatibility, high in safety and good in flexibility and compliance, the array micropore structure of the tube wall can effectively conduct aqueous humor diversion, meanwhile, device failure caused by channel blockage is avoided, and the service life of the device is prolonged. The heparin coating on the surface can effectively prevent tissue fluid or blood from forming scars or thrombus on the surface of the micro-drainage tube, and in addition, the micro-drainage tube is loaded with therapeutic drugs, so that the reactions of inflammation, allergy, immunity and the like of surrounding tissues can be inhibited after the therapeutic drugs are slowly released.

Description

technical field [0001] The invention relates to the technical field of ophthalmic medical biomaterials, in particular to a method for preparing an artificial aqueous humor micro-drainage tube with drug slow-release function. Background technique [0002] Glaucoma is an irreversible blinding eye disease, which is characterized by optic disc damage, vision loss and related visual field defects. The main factors of the onset are pathological elevated intraocular pressure and insufficient blood supply to the optic nerve, but the factors that induce glaucoma are more complicated . At present, the main clinical treatment method is to reduce intraocular pressure. The treatment of early glaucoma to reduce intraocular pressure mainly adopts drugs, but long-term drug resistance will develop in patients, and most patients are already in the middle and late stages when they see a doctor. The needs cannot be met, so surgery is required for treatment. Currently, glaucoma filtration surg...

AI Technical Summary

Problems solved by technology

In filtering surgery, trabeculectomy is still the main method of diagnosis and treatment to control the progress of glaucoma in my country at present stage, but there are various complications such as early shallow anterior chamber, hyphema, filtering bleb wrapped , choroidal detachment or delayed choroidal hemorrhage, etc., and the fibrosis and scarring of the filtering bleb will further lead to the failure of the operation

[0003] In recent years, various aqueous humor drainage implants have been developed for the treatment of glaucoma, and have achieved good results, but there are still various problems, such as relatively rigid structure, unsatisfactory biocompatibility, implants Strong inflammatory reaction and tissue hyperplasia in the surrounding tissue, which may even lead to implant displacement and blockage, resulting in device failure requiring secondary surgery, etc.

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