Traditional Chinese medicine syndrome differentiation type discrimination model and system in breast cancer chemotherapy period and construction method of traditional Chinese medicine syndrome differentiation type discrimination model
A technology for discriminating models and building methods, applied in medical informatics, medical automated diagnosis, computer-aided medical procedures, etc., can solve problems that cannot be completed by one person's experience, and achieve the effect of avoiding subjective errors
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Embodiment 1
[0080] Example 1 Collection and entry of TCM syndrome information for breast cancer chemotherapy patients
[0081]1) Source of cases: Collected from December 2019 to January 2021, a total of 500 patients with malignant breast tumors treated with chemotherapy at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine and Cancer Hospital Affiliated to Shanghai Fudan University , 400 cases are used as a test set for model building; 100 cases are used as a validation set for model validation.
[0082] 2) Diagnostic criteria: refer to "Surgery" (editor-in-chief: Chen Xiaoping, Beijing: People's Health Publishing House, 2nd edition in August 2010). Combined with the patient's clinical manifestations, physical examination, imaging examination, and pathological examination, it was diagnosed as breast cancer.
[0083] 3) Inclusion criteria: ① female; ② breast cancer patients with clear pathological diagn...
Embodiment 2
[0086] Example 2 Establishment of TCM Syndrome Type Discrimination Model during Breast Cancer Chemotherapy
[0087] 1) SPSS 21.0 software was used to statistically analyze the data in the TCM syndrome database during chemotherapy for breast cancer. According to the four syndrome types of liver depression and yin deficiency, qi and yin deficiency, spleen deficiency and blood deficiency, and qi stagnation and blood stasis, TCM syndrome differentiation is carried out. The original weight coefficient corresponding to each syndrome item in the relationship between syndrome differentiation and typing during chemotherapy of breast cancer (see Table 1-4) is used as the score ratio. Table 1-4 is the logistic regression analysis results of clustering into four categories (reserving syndrome items with original weight coefficient >0), where B represents the regression coefficient, and p represents the probability.
[0088] Table 1. Logistic regression analysis results of liver depressio...
Embodiment 3
[0120] Example 3 Verification of TCM Syndrome Type Discrimination Model during Chemotherapy for Breast Cancer
[0121] The 100 patients in the verification set included in Example 1 were compared with the degree of agreement between the TCM syndrome types determined by the TCM syndrome differentiation model established in Example 2 and the TCM syndrome types determined by experts. Taking the results of expert syndrome differentiation as the gold standard, calculate the sensitivity, specificity and accuracy of the TCM syndrome differentiation model for breast cancer chemotherapy period established in Example 2 relative to expert syndrome differentiation. The results are as follows: ①Syndrome of liver depression and yin deficiency: sensitive Degree: 0.70, Specificity: 0.91, Accuracy: 0.87, Youden Index: 0.66; ② Qi and Yin Deficiency Syndrome: Sensitivity: 0.65, Specificity: 0.95, Accuracy: 0.84, Youden Index: 0.86; ③ Spleen Deficiency Blood deficiency syndrome: sensitivity: 0.96...
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