Nanogold antibacterial agent as well as preparation method and application thereof

A technology of antibacterial agent and nano gold, which is applied in the direction of nanotechnology, nanomedicine, nanotechnology, etc., can solve the problems of inability to have antibacterial effect against Gram-positive bacteria and Gram-negative bacteria at the same time, and poor antibacterial effect, and achieve Excellent antibacterial effect and simple preparation process

Active Publication Date: 2022-03-15
THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
View PDF6 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the poor antibacterial effect of existing gold nano antibacterial agents, and the defects and deficiencies that the antibacterial effects of anti-Gram-positive bacteria and Gram-negative bacteria cannot be simultaneously provided, and a preparation of a nano-gold antibacterial agent is provided Method, through the synergistic effect of cationic surfactant and specific sulfhydryl small molecule reagent, the modified Xiong Aiguo is enhanced, the overall antibacterial effect is improved, and it can selectively resist the production of Gram-positive bacteria and Gram-negative bacteria individually or simultaneously antibacterial effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nanogold antibacterial agent as well as preparation method and application thereof
  • Nanogold antibacterial agent as well as preparation method and application thereof
  • Nanogold antibacterial agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] A preparation method of nano gold antibacterial agent, comprising the steps of:

[0078] S1. In the chloroauric acid solution with a mass concentration of 12%, add a sodium borohydride solution with a mass concentration of 2% to obtain a mixed solution A, and feed nitrogen into it;

[0079] S2. Continue to add the ethylene glycol solution whose volume fraction is 6% to the above mixed solution A to obtain the mixed solution B;

[0080] S3. In mixed solution B, add the dimethyl diallyl ammonium chloride of 0.6% total solution fraction to obtain mixed solution C;

[0081] S4. Add 0.4% 4-mercaptobenzoic acid in the total volume fraction of the solution to the mixed solution C, under a nitrogen atmosphere, the reaction temperature is 2°C, the stirring rate is 50rpm / min, and the nitrogen rate is 35mL / min, and the reaction time is 3h to obtain nano Gold antimicrobial.

Embodiment 2

[0083] A preparation method of nano gold antibacterial agent, comprising the steps of:

[0084] S1. In the chloroauric acid solution with a mass concentration of 15%, add a sodium borohydride solution with a mass concentration of 4% to obtain a mixed solution A, and feed nitrogen into it;

[0085] S2. Continue to add the ethylene glycol solution whose volume fraction is 8% to the above mixed solution A to obtain the mixed solution B;

[0086] S3. In mixed solution B, add the dimethyl diallyl ammonium chloride of 1.2% total solution fraction to obtain mixed solution C;

[0087] S4. Add 1.5% of the total volume fraction of 3-mercapto-2-pentanone in the mixed solution C, under nitrogen atmosphere, the reaction temperature is 4°C, the stirring rate is 100rpm / min, the nitrogen rate is 35mL / min, and the reaction time is 5h , to obtain nano gold antibacterial agent.

Embodiment 3

[0089] A preparation method of nano gold antibacterial agent, comprising the steps of:

[0090] S1. In the chloroauric acid solution with a mass concentration of 20%, add a sodium borohydride solution with a mass concentration of 6% to obtain a mixed solution A, and feed nitrogen into it;

[0091] S2. Continue to add the ethylene glycol solution whose volume fraction is 10% to the above mixed solution A to obtain the mixed solution B;

[0092] S3. In the mixed solution B, add 1.7% cetyltrimethylammonium bromide of the total solution fraction to obtain the mixed solution C;

[0093] S4. Add 1.2% 3-mercaptopropionic acid in the total volume fraction of the solution to the mixed solution C, under a nitrogen atmosphere, the reaction temperature is 8°C, the stirring rate is 200rpm / min, and the nitrogen rate is 35mL / min, and the reaction time is 6h to obtain nano Gold antimicrobial.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a nanogold antibacterial agent as well as a preparation method and application thereof, and belongs to the technical field of antibacterial materials. The preparation method of the nanogold antibacterial agent comprises the following steps: S1, mixing a chloroauric acid solution with a sodium citrate and/or sodium borohydride solution to obtain a mixed solution A; s2, continuously adding an ethanol or ethylene glycol solution into the mixed solution A to obtain a mixed solution B; s3, adding a cationic surface active agent into the mixed solution B to obtain a mixed solution C; and S4, adding a sulfydryl micromolecule reagent into the mixed solution C, and reacting in an inert gas atmosphere to obtain the nanogold antibacterial agent. The nano-gold antibacterial agent with an excellent antibacterial effect is prepared by combining a specific cationic surfactant with a sulfydryl small molecule reagent for modification, and the nano-gold antibacterial agent not only has an excellent antibacterial effect on gram-positive bacteria, but also has an excellent antibacterial effect on gram-negative bacteria; the composition is effectively applied to object surface bacteriostasis and treatment of burns, scalds, various wound infections and the like.

Description

technical field [0001] The invention relates to the technical field of antibacterial materials, more specifically, to a nano-gold antibacterial agent and its preparation method and application. Background technique [0002] With the widespread use of antibacterial drugs, the treatment of infectious diseases faces new challenges, and bacteria have developed resistance to antibiotics. With the continuous use of antibiotics, the problem of bacterial resistance is getting worse. On the one hand, drug-resistant bacteria will cause all kinds of antibiotics to lose their therapeutic effect, and the growth and reproduction of bacteria will become more and more difficult to control; on the other hand, they will seriously endanger human health and even threaten the human living environment. In recent years, according to relevant reports, the overuse and abuse of antibiotics has led to a trend of increasing bacterial resistance year by year. Multidrug-resistant and extensively drug-r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/242A61K47/18A61K47/20A61K47/22A61P31/04A61P17/02B82Y5/00B82Y40/00
CPCA61K33/242A61K47/186A61K47/20A61K47/22A61P31/04A61P17/02B82Y5/00B82Y40/00Y02A50/30
Inventor 郑文富冯超
Owner THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap