Analysis method of hyssopus officinalis volatile oil and application of hyssopus officinalis volatile oil in preparation of medicine for treating hormone-resistant asthma

Abstract

The invention relates to an analysis method of hyssopus officinalis volatile oil and application of the hyssopus officinalis volatile oil in preparation of a medicine for treating hormone-resistant asthma, which comprises qualitative and relative quantitative analysis of chemical components of the hyssopus officinalis volatile oil, construction of a hormone-resistant asthma model and grouped administration. The influence of the hyssopus officinalis volatile oil on the number of inflammatory cells in alveolar lavage fluid and peripheral blood of a mouse with the hormone-resistant asthma is researched, and the influence of the hyssopus officinalis volatile oil on the concentration of interleukin-17 (IL-17) and granulocyte colony stimulating factor (G-CSF) in BALF and lung tissues of the mouse with the hormone-resistant asthma is researched. The influence of the hyssopus officinalis volatile oil on pathological changes of lung tissues of mice with hormone-resistant asthma is studied, and the chemical components of the hyssopus officinalis volatile oil and the pharmacological action of the hyssopus officinalis volatile oil for treating the hormone-resistant asthma are integrally evaluated according to the studies. The hyssopus officinalis volatile oil has great significance in new drug research and clinical application of the hyssopus officinalis volatile oil for treating the hormone-resistant asthma.

Description

technical field [0001] The invention belongs to the field of medicine, and more specifically, relates to an analysis method of the volatile oil of the herb elixir and its application in the preparation of a medicine for treating steroid-resistant asthma. Background technique [0002] Steroid-resistant asthma (SRA) refers to asthma that is ineffective or ineffective in treatment with oral glucocorticoids (GC). So far, the pathogenesis of SRA is still not fully understood. The proven mechanism of GC resistance effect includes: glucocorticoid receptor (glucocorticoid receptor, GR, GRα and GRβ are the two main subtypes of GR) abnormality, imbalance of immune regulation mechanism, abnormal activity of histone acetylase, Abnormal heat shock protein HSP90, transcription factor AP-1 and NF-κB abnormalities, etc. [0003] GR abnormality mainly manifests as increased GRβ expression, decreased GC-GRα affinity, abnormal GRα nuclear translocation, and GR phosphorylation. Among them, G...

AI Technical Summary

Problems solved by technology

However, long-acting β-receptor agonists need to be used in combination with other non-hormonal antiallergic drugs; inhaled anticholinergic drugs and leukotriene receptor antagonists are only effective for some patients; methotrexate is effective for the digestive system, bone marrow and kidney Impaired, hepatotoxic in high doses

2) Immunosuppressants, such as cyclosporine A, immunoglobulin, etc., can reduce the dosage of hormones in patients with SRA, but immunosuppressants are expensive and have many side effects

However, there is no report on the therapeutic effect of the volatile oil of the herb elixir on SRA.

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