Improved preparation method of big bupleurum decoction

A technology of Dachaihu Decoction and decoction, applied to medical preparations containing active ingredients, medical formulas, instruments, etc., which can solve the problems of no preparation process, unclear functional material basis, preparation method and detection method of Dachaihu Decoction Insufficient perfection and other issues to achieve the effect of improving and reconciling Shaoyang

Pending Publication Date: 2022-03-25
北京橘井健康科技集团有限公司
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  • Claims
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AI Technical Summary

Problems solved by technology

[0004] Dachaihu Decoction is widely used in clinical practice, with stable and clear curative effect, but its specific functional material basis is still unclear, and the current preparation method and detection method of Dachaihu Decoction are not

Method used

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  • Improved preparation method of big bupleurum decoction
  • Improved preparation method of big bupleurum decoction
  • Improved preparation method of big bupleurum decoction

Examples

Experimental program
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Effect test

Embodiment

[0041] 1. Screening of Q-markers corresponding to the effect of Dachaihu Decoction on reconciling Shaoyang Neixie heat stagnation

[0042] use as figure 1 The procedure shown in is to screen the Q-markers corresponding to the efficacy of Dachaihu Decoction and the effect of relieving Shaoyang Neixie heat knot, and the results are shown in Table 1 below.

[0043] Table 1: Q-markers corresponding to the efficacy of Dachaihu Decoction in reconciling Shaoyang Neixie heat stagnation

[0044]

[0045]

[0046] Note: The efficacy in bold is the key efficacy; the ingredients in bold are Q-markers.

[0047] As shown in Table 1, according to the Q-markers screening results, the main active substance saikosaponin B related to the efficacy of Dachaihu Tang 2 , baicalin, baicalein, wogonin, naringin, neohesperidin, hesperidin and paeoniflorin were used as the main efficacy markers for screening the preparation method of the improved Dachaihu decoction.

[0048] Therefore, the Dach...

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Abstract

In the screening process of the preparation method of the large radix bupleuri decoction, the Q-marker concept is introduced for the first time, and the large radix bupleuri decoction is screened according to the Q-marker screening result; main active substances, such as saikoside B2, baicalin, baicalein, wogonoside, naringin, neohesperidin, hesperidin and paeoniflorin, which are related to the drug effect of the big bupleurum decoction are taken as main efficacy markers for screening the preparation method of the big bupleurum decoction, and the improved preparation method of the big bupleurum decoction is screened through single factor analysis and orthogonal design. The large bupleurum decoction prepared by the method has obviously improved effects of relieving Shaoyang and purging heat accumulation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine modernization, and in particular relates to a preparation method of an improved Dachaihu decoction. Background technique [0002] Dachaihu Decoction comes from Zhang Zhongjing's "Treatise on Febrile and Miscellaneous Diseases". It is composed of Bupleurum, Scutellaria, Paeoniae Alba, Pinellia, Ginger, Citrus aurantium, Jujube, and Rhubarb. In the theory of Chinese medicine, Shaoyang includes gallbladder and triple burner. If Shaoyang is affected by evil, the cardinal mechanism is unfavorable, and the stagnation of liver and gallbladder qi will inevitably affect the qi transformation function of the triple burner. Fullness, or abdominal pain, etc., if the spleen and stomach are injured, the qi movement is blocked, the soil is blocked, the wood is stagnant, the dryness and heat are combined with dregs, and they accumulate in the stomach and intestines, blocking the flow of qi in the inter...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/10A61P1/16G01N30/06G01N30/74
CPCA61K36/233A61K36/539A61K36/71A61K36/65A61K36/8888A61K36/752A61K36/9068A61K36/725A61K36/708A61P1/10A61P1/16G01N30/06G01N30/74A61K2236/331A61K2236/39A61K2300/00
Inventor 魏胜利张燕玲吕恬仪刘亚楠张林张媛赵婷胡秀华刘凤波
Owner 北京橘井健康科技集团有限公司
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