Flavored common goldenrop granules and preparation method thereof

A technology of Bupleurum and its composition, applied in the field of flavored Xiaobupleurum granules and its preparation, can solve the problems of reduced drug efficacy, aggravated toxic and side effects, drug leakage, etc., and achieve the effect of improving drug efficacy

Active Publication Date: 2020-04-10
东莞市中医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the historical changes such as the long span of time, huge differences in geographical environments, and differences in human physique, classic prescriptions are far from meeting the needs of modern diseases.
[0003] At the same time, the current traditional Chinese medicine has complex chemical components and difficult quality control, and the prior art Xiaobupleurum is often considered to have low active ingredients and low purity, thereby reducing the efficacy of the medicine.
In order to increase the content of active ingredients of traditional Chinese medicines in the prior art, a variety of solubilization methods have been adopted. However, different solubilization methods also have certain defects, such as the method of using surfactant compounds used in emulsification, which has the advantages of adding There are hidden dangers of severe toxicity and side effects; another example is the method of using phospholipid complex coating, which is prone to drug leakage and poor stability; another example is the method of cyclodextrin embedding, which has low drug loading and has characteristics on the size of drug molecules. asked questions

Method used

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  • Flavored common goldenrop granules and preparation method thereof
  • Flavored common goldenrop granules and preparation method thereof
  • Flavored common goldenrop granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, a kind of Xiao Bupleurum composition with flavoring

[0056] The flavored Xiao Bupleurum composition is made from the following raw materials by weight:

[0057] Bei Bupleurum 250g; Scutellaria baicalensis 167g; Codonopsis 167g; Pinellia 167g; Ginger 167g;

[0058] The preparation method of the flavored Xiao Bupleurum composition comprises the following steps:

[0059] S1) Take the formula amount of Bupleurum bupleurum, Scutellaria baicalensis, Codonopsis pilosula, Pinellia chinensis, ginger, jujube, licorice, dried ginger, Coptis chinensis, Poria cocos and Atractylodes macrocephala, add water and decoct 3 times, each time for 1.5h, to obtain a decoction ;

[0060] S2) Filtrate the decoction in step S1, concentrate the filtrate into a clear paste with a relative density of 1.10-1.20 (60°C thermal measurement), and dry to obtain the extract powder, that is, the flavored Xiaobupleurum composition.

Embodiment 2

[0061] Embodiment 2, a kind of Xiao Bupleurum composition with flavoring

[0062] The flavored Xiao Bupleurum composition is made from the following raw materials by weight:

[0063] Bei Bupleurum 250g; Scutellaria baicalensis 167g; Codonopsis 167g; Pinellia 167g; Ginger 167g;

[0064] The preparation method of the flavored Xiao Bupleurum composition comprises the following steps:

[0065] S1) Take the formula amount of Bupleurum bupleurum, Scutellaria baicalensis, Codonopsis pilosula, Pinellia chinensis, ginger, jujube, licorice, dried ginger, Coptis chinensis, Poria cocos and Atractylodes macrocephala, add water and decoct 3 times, each time for 1.5h, to obtain a decoction ;

[0066]S2) filtering the decoction in step S1, concentrating the filtrate into a clear paste with a relative density of 1.10-1.20 (60°C thermal measurement), drying to obtain extract powder;

[0067] S3) Mix and stir the extract powder, the purification reagent and water, place in a water bath at 7...

Embodiment 3

[0070] Embodiment 3, a kind of Xiao Bupleurum composition with flavoring

[0071] The flavored Xiao Bupleurum composition is made from the following raw materials by weight:

[0072] Bei Bupleurum 225g; Scutellaria baicalensis 180g; Codonopsis 180g; Pinellia 180g; Ginger 167g;

[0073] The preparation method of the flavored Xiao Bupleurum composition comprises the following steps:

[0074] S1) Take the formula amount of Bupleurum bupleurum, Scutellaria baicalensis, Codonopsis pilosula, Pinellia chinensis, ginger, jujube, licorice, dried ginger, Coptis chinensis, Poria cocos and Atractylodes macrocephala, add water and decoct 3 times, each time for 1.5h, to obtain a decoction ;

[0075] S2) filtering the decoction in step S1, concentrating the filtrate into a clear paste with a relative density of 1.10-1.20 (60°C thermal measurement), drying to obtain extract powder;

[0076] S3) Mix and stir the extract powder, purification reagent and water, place in a water bath at 70° ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to flavored common goldenrop granules and a preparation method thereof. A flavored common goldenrop composition is prepared from the following raw material medicines by weight: 225 to 275 g of bupleurum chinense; 150 to 200 g of radix scutellariae; 150 to 200 g of codonopsis pilosula; 150 to 200g of rhizoma pinellinae praeparata; 150 to 200 g of raw ginger; 475 to 525 g of Chinese dates; 75 to 125 g of honey-fried licorice roots; 75 to 125 g of dried ginger; 25 to 75 g of coptis chinensis;225 to 275 g of poria cocos; and 150 to 200 g of bighead atractylodes rhizome. The modified common goldenrop granules improve the contents of effective components including liquiritin, baicalin, berberine hydrochloride, wogonoside, baicalein and ammonium glycyrrhizinate in the raw material medicines, and play excellent roles in relieving shaoyang, harmonizing the stomach, calming the adverse-rising energy, invigorating the spleen and eliminating lumps.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to flavored Xiaobupleurum granules and a preparation method thereof. Background technique [0002] Xiaochaihu Decoction is an effective traditional Chinese medicine prescription summed up by Chinese medical sages in the Eastern Han Dynasty based on the symptoms of patients with spleen and stomach diseases at that time. It has been used for more than two thousand years, and later generations call it a classic prescription. The composition of the classic prescription is: Bupleurum, Scutellaria, Ginseng, Banxiaqing, Licorice Sunburn, Ginger Cut and Jujube Break. However, with the historical changes such as the long span of time, huge differences in geographical environments, and differences in human physique, classic prescriptions are far from meeting the needs of modern diseases. [0003] At the same time, the current traditional Chinese medicine has...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K47/18A61K47/36A61K9/16A61P1/14A61P1/00
CPCA61K9/1617A61K9/1652A61K36/076A61K36/233A61K36/284A61K36/344A61K36/484A61K36/539A61K36/718A61K36/725A61K36/8888A61K36/9068A61K47/18A61K47/36A61K2236/331A61K2236/39A61K2236/51A61P1/00A61P1/14A61K2300/00
Inventor 周爱军刘焱文吴谋
Owner 东莞市中医院
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