Application of positive ion supramolecular organic framework solid material in biotoxin adsorption

An organic framework and biotoxin technology, applied in the field of biomedicine, can solve the problems of poor blood compatibility, poor selectivity, and low adsorption capacity, and achieve rapid and efficient adsorption, high biocompatibility, and high adsorption capacity.

Active Publication Date: 2022-04-01
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low adsorption capacity, poor selectivity, poor hemocompatibility and adsorption effectiveness are important factors that limit the application and therapeutic effect of hemoperfusion
How to quickly and efficiently remove bilirubin in the presence of high concentrations of albumin remains a challenge

Method used

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  • Application of positive ion supramolecular organic framework solid material in biotoxin adsorption
  • Application of positive ion supramolecular organic framework solid material in biotoxin adsorption
  • Application of positive ion supramolecular organic framework solid material in biotoxin adsorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Preparation and characterization of supramolecular organic framework solid material sSOFs.

[0046] The preparation method of the positive ion supramolecular organic framework material aqueous solution provided by the present invention refers to the document Nat.Commun.2014,5:5574. Water-insoluble sSOFs solids can be obtained after evaporating the solvent. Such as figure 1 As shown, the sSOF-3 solid material retains its porosity and order in solution. Directly using the solutions of CB8, A1~A4, SOF-1~4 to adsorb bilirubin cannot effectively remove bilirubin from the solution.

Embodiment 2

[0047] Example 2: Study on the adsorption kinetics of sSOFs on bilirubin.

[0048] Prepare a certain concentration of bilirubin (150mg / L) solution, add different weights of sSOFs solids, so that the concentrations of sSOFs solids are 1mg / mL and 2mg / mL respectively, stir the solution, and test the bilirubin concentration after a certain period of time. Absorbance. With the prolongation of adsorption time, the absorbance of bilirubin decreased continuously until the equilibrium. Such as Figure 2 to Figure 5 As shown, by making the graph of the change of bilirubin concentration over time, it can be confirmed that the sSOFs solid material can quickly absorb bilirubin, and the bilirubin concentration reaches a normal level in about 10 minutes. Such as Image 6 As shown, the adsorption rate of activated carbon and anion exchange resin D201 material to bilirubin is much slower than that of sSOFs solid material by making the graph of the change of bilirubin concentration with time...

Embodiment 3

[0049] Example 3: Study on the adsorption thermodynamics of sSOFs on bilirubin.

[0050] Prepare different concentrations of bilirubin (150mg / L) solutions, add sSOFs solids of the same weight to each group, so that the concentration of sSOFs solids is 2mg / mL, stir the solution, test the absorbance of bilirubin in each group of solutions after 2 hours, Determine the amount of bilirubin adsorbed. Data were processed and fitted with a linear Langmuir equation and a linear Friedrich equation ( Figure 9 with Figure 10 ). The fitting results of the two linear equations are shown in Table 2. It can be confirmed that the thermodynamics of the bilirubin adsorption process on sSOFs solid materials is more consistent with the linear Friedrich equation. At the same time, the data were fitted with the nonlinear Langmuir thermodynamic equation and the nonlinear Friedrich thermodynamic equation ( Figure 11 to Figure 14 ). The nonlinear fitting results are shown in Table 3, and it can...

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PUM

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to application of a positive ion supramolecular organic framework solid material in adsorption of biotoxin. The supramolecular organic framework material is a positive ion type supramolecular organic framework material (sSOFs) formed by tetrahedral molecules and CB [8] in a water phase through host-guest interaction, and a water-insoluble sSOFs solid is obtained after a solvent is evaporated; adsorption kinetics and thermodynamics experiments prove that the supramolecular organic framework solid material can quickly and efficiently adsorb negatively charged bilirubin, so that the concentration of the bilirubin is reduced to a normal level. Even under the physiological condition that high-concentration serum protein exists, the adsorption efficiency of the sSOFs solid to bilirubin still reaches 90%.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of supramolecular organic framework solid materials in adsorption and removal of biological toxins. Background technique [0002] Acute liver failure (ALF) is a syndrome with multiple complications, including rapid deterioration of liver function, irreversible protein synthesis impairment, and brain damage. Its pathogenesis is diverse and its mortality rate is high ( ≥30% for adults, ≥13% for children). The main clinical feature of acute liver failure is a high concentration of bilirubin in the serum. Bilirubin is an endogenous toxin produced by the metabolism of heme derived from aging hemoglobin in human blood. Bilirubin can be carried by blood protein (albumin) to the liver to form a complex of glucuronic acid and bilirubin, which can be further excreted into bile for final decomposition. However, due to the impaired liver function of ALF pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/22A61M1/36B01D15/08
CPCY02A50/30
Inventor 黎占亭张丹维刘亚敏王辉王泽坤
Owner FUDAN UNIV
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