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A kind of multifunctional hemostatic material and preparation method thereof

A hemostatic material and multi-functional technology, which can be used in the field of medical materials and can solve problems such as unusable bleeding wounds

Active Publication Date: 2022-06-28
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostasis of chitosan has certain limitations in application, and it can only be used for small areas of hemostasis, and cannot be used for large areas of bleeding wounds

Method used

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  • A kind of multifunctional hemostatic material and preparation method thereof
  • A kind of multifunctional hemostatic material and preparation method thereof
  • A kind of multifunctional hemostatic material and preparation method thereof

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preparation example Construction

[0025] A method for preparing a multifunctional hemostatic material provided in the embodiment of the present invention includes the following steps:

[0026] S1. Preparation of Modified Pluronic F127

[0027] Please refer to figure 1 In (a), the modified Pluronic F127 is the aldehydeylation reaction of Pluronic F127. The general reaction steps include: after mixing F127, organic solvent, p-formylbenzoic acid, 4-dimethylaminopyridine and dicyclohexylcarbodiimide, extracting with saturated salt solution, and then precipitating activated F127 with organic solvent ; After mixing and reacting activated F127 with cysteamine and organic solvent, it is separated and dried.

[0028] The specific reaction steps can be as follows: respectively weighing 20g PEO-PPO-PE0 molecule, 1g p-formylbenzoic acid and 50mg 4-dimethylaminopyridine in a three-necked flask, then adding 150mL dichloromethane to the above reaction flask, Next, 5.48 g of dicyclohexylcarbodiimide was added. Under nitro...

Embodiment 1

[0054] This embodiment provides a method for preparing a multifunctional hemostatic material. The multifunctional hemostatic material is composed of chitosan solution, aldehyde-formed F127, polydopamine-coated short fiber and polydopamine particles, and the multi-functional hemostatic material includes the following steps :

[0055] 1. Preparation of Components in Gel Precursor Solution

[0056] (1) Preparation of chitosan solution: take 0.33g of chitosan (Mn=100-200kDa, degree of deacetylation>95%) and dissolve it in 10mL of acetic acid aqueous solution (concentration of 0.1M) to obtain 0.033g / mL of chitosan Chitosan solution.

[0057] (2) Preparation of formylation F127 solution: First, prepare formylation F127. The specific operation steps are to weigh 20g PEO-PPO-PE0 molecule, 1g p-formylbenzoic acid and 50mg 4-dimethylaminopyridine in three necks respectively. flask, and then 150 mL of dichloromethane was added to the above reaction flask, followed by 5.48 g of dicycloh...

Embodiment 2

[0067] The present embodiment provides a preparation method of a multifunctional hemostatic material. The multifunctional hemostatic material is composed of a quaternized chitosan solution, an aldehyde-based F127, a polydopamine-coated drug-loaded short fiber, and a tranexamic acid drug. It includes the following steps:

[0068] 1. Preparation of Components in Gel Precursor Solution

[0069] (1) Preparation of quaternized chitosan solution: 1 g of chitosan (Mn=100-200kDa, degree of deacetylation>95%) was dissolved in 10 mL of acetic acid aqueous solution (concentration of 0.1 M) to obtain 0.1 g / mL chitosan solution.

[0070] (2) Preparation of formylation F127 solution: First, prepare formylation F127. The specific operation steps are to weigh 20g PEO-PPO-PE0 molecule, 1g p-formylbenzoic acid and 50mg 4-dimethylaminopyridine in three necks respectively. flask, and then 150 mL of dichloromethane was added to the above reaction flask, followed by 5.48 g of dicyclohexylcarbodii...

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Abstract

The invention discloses a multifunctional hemostatic material and a preparation method thereof, and relates to the technical field of medical materials. The preparation method of the multifunctional hemostatic material includes: (1) preparation of modified Pluronic F127: subjecting F127 to an aldylation reaction; (2) preparation of modified drug-loaded nanofibers: degradable polymers, anti-inflammatory drugs Mix with an organic solvent to form a solution to be spun, and obtain drug-loaded nanofibers after spinning; deposit polydopamine on the drug-loaded nanofibers; (3) preparation of blood-promoting materials: chitosan or chitosan The derivative, the modified Pluronic F127, the modified drug-loaded nanofiber and the hemostatic or healing-promoting drug are dissolved and dispersed in water and mixed to react. The prepared hemostatic material has moisture retention, injectability and biocompatibility, and has the functions of antibacterial, anti-inflammatory and promoting wound healing.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a multifunctional hemostatic material and a preparation method thereof. Background technique [0002] At present, there are various types of medical hemostatic materials, and the hemostatic materials that have been approved for clinical use can be roughly divided into: (1) coagulation factor concentrates, which mainly use the physical and chemical properties of the material itself to absorb water in the blood and promote the wound site. The coagulation components are aggregated and concentrated, thereby accelerating coagulation. (2) Mucoadhesive, the hemostatic material exhibits strong tissue adhesion, which can physically seal the bleeding wound without participating in the coagulation cascade. (3) Procoagulant supplements, which work by providing a high concentration of coagulation factors locally in the bleeding wound and directly activating the coagulation cascade. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/00A61K41/00A61P31/04
CPCA61L24/08A61L24/046A61L24/001A61L24/0015A61L24/0031A61K41/0052A61P31/04A61L2400/04A61L2300/404A61L2300/41A61L2300/412A61L2400/06A61L2400/12A61L2300/418A61L2300/602A61L2300/402A61L2300/216A61L2300/214C08L71/02C08L79/02C08L5/08C08L67/04
Inventor 杨光曹敏林莉敏许豪良杨婷何洋蒋正鑫
Owner SOUTHWEST JIAOTONG UNIV