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Collagen/biological ceramic porous bone implant and preparation method thereof

A technology of bioceramics and collagen, applied in medical science, prosthesis, etc., can solve the problems of poor material strength and cannot be applied, and achieve good bone conduction, promote regeneration and repair, and promote biological activity.

Active Publication Date: 2022-04-15
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen in organic materials is the main component of bone organic matter, which can stop bleeding, promote tissue healing, and promote bone mineralization, etc., but there are also some problems, such as bone defects reappear due to rapid degradation after bone grafting, and poor material strength Cannot be applied to bone defects in load-bearing parts, etc.

Method used

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  • Collagen/biological ceramic porous bone implant and preparation method thereof
  • Collagen/biological ceramic porous bone implant and preparation method thereof
  • Collagen/biological ceramic porous bone implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A kind of collagen / bioceramic porous bone implant, its preparation method comprises the steps ( figure 2 Be the preparation flowchart of the present invention):

[0046] (1) Preparation of collagen solution: Dissolve the lyophilized product of natural collagen with a triple helix structure in distilled water at a dissolving temperature of 10°C to obtain 200mL of 2.5mg / g low-concentration collagen solution and 100mL of 7.0mg / g collagen solution respectively. g high-concentration collagen solution;

[0047] (2) Preparation of denatured collagen: put 100mL of 2.5mg / g low-concentration collagen solution in step (1) in an oven, set the temperature to 105°C, and after heat reaction for 1h, centrifuge at 4000r / min for 10min to take the supernatant, to obtain denatured collagen solution;

[0048] (3) screening bioceramics: get porous β-tricalcium phosphate bioceramics with a porosity of 65%, and get 28 orders with a stainless steel standard sieve, and the bioceramics particl...

Embodiment 2

[0063] A collagen / bioceramic porous bone implant, the preparation method of which comprises the steps of:

[0064] (1) Collagen solution preparation: Dissolve the lyophilized product of natural collagen with a triple helix structure in distilled water at a temperature of 10°C to obtain 200 mL of a low-concentration 3.0 mg / g collagen solution and 100 mL of a 8.0 mg / g collagen solution, respectively. g high-concentration collagen solution;

[0065] (2) Preparation of denatured collagen: put 100mL of 3.0mg / g low-concentration collagen solution in step (1) in an oven, set the temperature to 105°C, and after heat reaction for 1h, centrifuge at 4000r / min for 10min to take the supernatant to obtain Denatured collagen solution;

[0066] (3) screening bioceramics: get porous α-tricalcium phosphate bioceramics with a porosity of 65%, and get 18 meshes with a stainless steel standard sieve, the bioceramics particles retained by 30 meshes, the particle diameter is 0.5~0.9mm as Screened ...

Embodiment 3

[0073] A collagen / bioceramic porous bone implant, the preparation method of which comprises the steps of:

[0074] (1) Preparation of collagen solution: Dissolve the lyophilized product of natural collagen with a triple helix structure in distilled water at a temperature of 12°C to obtain 200 mL of 3.5 mg / g low-concentration collagen solution and 100 mL of 9.0 mg / g collagen solution respectively. g high-concentration collagen solution;

[0075] (2) Preparation of denatured collagen: put 100mL of 3.5mg / g low-concentration collagen solution in step (1) in an oven, set the temperature to 110°C, and after heat reaction for 1.5h, centrifuge at 4500r / min for 10min to take the supernatant. Obtain denatured collagen solution;

[0076] (3) Screening bioceramics: take porous hydroxyapatite bioceramics with a porosity of 70%, use a stainless steel standard sieve to pass through 14 mesh, 24 mesh intercepted bioceramic particles, and the particle size is 0.7 ~ 1.2mm as screening bioceram...

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Abstract

The invention discloses a collagen / biological ceramic porous bone implant and a preparation method thereof. The preparation method comprises the following steps: (1) preparing collagen solutions with different concentrations; (2) preparing denatured collagen; (3) screening biological ceramics; (4) vacuum infusion; (5) preparing a dialysis collagen liquid; (6) preparing a mixed material; (7) filling and freeze-drying; and (8) vacuum drying. The collagen / biological ceramic porous bone implant prepared by the method has a porous structure and good mechanical properties, the biological activity, degradability and biocompatibility of the porous bone implant are promoted, and the collagen / biological ceramic porous bone implant has a huge application prospect in the field of biomedical material bone tissue engineering.

Description

technical field [0001] The invention relates to the technical field of biomaterial bone tissue engineering, in particular to a collagen / bioceramic porous bone implant and a preparation method thereof. Background technique [0002] As a country with a large population, with the process of population aging, the number of patients with bone defects caused by tumor resection, infection, trauma and congenital diseases is increasing every year. For the body, if the bone defect is small, it can self-repair through bone tissue regeneration, while the bone defect caused by the above reasons is generally large, and it needs to be repaired by bone graft or bone substitute material implantation. [0003] An ideal bone repair material should have the following biochemical properties: good biocompatibility, which can prevent the implant from producing inflammatory or toxic reactions in the body; good osteoinductivity, which can induce mesenchymal cell differentiation to stimulate bone gro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/46A61L27/56A61L27/58A61L27/50
Inventor 许亚丽程咏梅陆金婷石丽虹李红云
Owner 无锡贝迪生物工程股份有限公司
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