Antibody, preparation method thereof, coding nucleic acid and engineering cell

Abstract

The present disclosure relates to a method for preparing an antibody, an antibody, a nucleic acid encoding the antibody, and an engineered cell. The antibody provided by the invention can resist severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and is good in specificity, high in sensitivity and excellent in pathogen neutralization effect.

Description

technical field [0001] The present disclosure relates to the field of biotechnology, in particular, to a method for preparing an antibody, an antibody, a nucleic acid encoding the antibody, and an engineered cell. Background technique [0002] Neutralizing antibodies are antibodies that are produced when pathogenic microorganisms invade the body. When pathogenic microorganisms invade cells, they need to rely on the specific molecules expressed by the pathogen itself to bind to the receptors on the cells to infect the cells and further expand. Neutralizing antibodies are certain antibodies produced by B lymphocytes, which can bind to antigens on the surface of pathogenic microorganisms, thereby preventing the pathogenic microorganisms from adhering to target cell receptors and invading cells. [0003] COVID-19, the novel coronavirus pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally as a severe disease pandemic (Callaway et ...

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Problems solved by technology

However, although the treatment with plasma from recovered patients is effective, it cannot be widely used due to the limited source of plasma.

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