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Quality detection method of roasted fructus aurantii immaturus

A quality inspection method and technology of citrus aurantium, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems such as the inability to monitor the quality of roasted citrus decoction pieces, the inability to reflect the quality of roasted citrus citrus decoction pieces, and the unfavorable quality control. , to achieve the effect of good chromatographic peak shape, simple quality detection method and short detection time.

Pending Publication Date: 2022-05-13
北京橘井健康科技集团有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, after solving the above-mentioned problems, a new problem has followed. At present, the method and standard for determining the content of the index components of the decoction pieces of Fructus Citrifolia prepared by the above-mentioned specific processing method have not been established, and there is no quantitative quality control index. It is impossible to monitor the internal quality of this decoction piece of citrus aurantium, nor can it reflect the quality of this decoction piece of citrus aurantium, which is not conducive to its quality control
In the quality detection method of Fructus Fructus Fructus Fructus Fructus Fructus Fructus and Fructus Fructus Fructus Decoction recorded in " Chinese Pharmacopoeia " (2020 edition), only the content of single component synephrine was detected, but according to the inventor's research this active component is not Zhizhishi is the main medicinal ingredient that plays a role in the prescription of Dachaihu Decoction

Method used

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  • Quality detection method of roasted fructus aurantii immaturus
  • Quality detection method of roasted fructus aurantii immaturus
  • Quality detection method of roasted fructus aurantii immaturus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Screening of Q-markers corresponding to the efficacy of Dachaihu Decoction for Neixie Yangming heat stagnation

[0034] use as figure 1 The process shown in the screen screens the Q-markers corresponding to the effect of Dachaihu Decoction on internal diarrhea, Yangming and heat accumulation, and obtains the Q-markers related to Aurantium citrus Fructus. The results are shown in Table 1 below.

[0035] Table 1: Q-markers related to Citrus aurantium and Dachaihu Tang Neixie Yangming heat-binding effect

[0036]

[0037] Note: The efficacy in bold is the key efficacy; the ingredients in bold are Q-markers.

Embodiment 2

[0039] The preparation method of the sun-dried citrus aurantium used in the experiment is to use the roasting method, with a baking temperature of 200 ° C, baked for 8 minutes, and the decoction pieces of the citrus aurantium are curled up, the edges are raised, the sac is protruding, there are oil stains, and the color is brown. Yellow, smells fragrant, tastes bitter, take it out, let it cool, and you can get it.

[0040] Table 2: Drug and Reagent Information Sheet

[0041]

[0042]

[0043] 1. Experimental method

[0044] Chromatographic conditions: using ODS C 18 Chromatographic column (4.6mm×250mm, 5 μm); mobile phase: acetonitrile (phase A), acetonitrile: water (take 2.0 g of sodium lauryl sulfate, dissolve it in 1000 mL of water, add 1 drop of phosphoric acid)=20:80 ( Phase B), carry out gradient elution according to the regulations in Table 4; flow rate: 1mL / min; column temperature: 25°C; ultraviolet detector, detection wavelength is 283nm.

[0045] Table 4:

[...

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Abstract

The invention belongs to the field of traditional Chinese medicine analysis, and provides a quality detection method suitable for roasted fructus aurantii immaturus prepared by adopting a specific processing method, the quality detection method utilizes high performance liquid chromatography (HPLC) to determine pharmacodynamic markers (Q-markers) of the efficacy of purging yang-clearing heat accumulation in a big radix bupleuri decoction, such as hesperidin, naringin and neohesperidin. According to the method, the content of the high-content active ingredient synephrine in the roasted fructus aurantii immaturus is measured, the chromatographic peak shape is good, the separation degree is high, and the detection time is short. The quality detection method is simple, accurate and good in reproducibility, and can provide a basis for comprehensively evaluating and controlling the quality of the special roasted immature bitter orange decoction piece for the big bupleurum decoction.

Description

technical field [0001] The invention belongs to the field of analysis of traditional Chinese medicines, and in particular relates to a method for detecting the quality of citrus aurantium. Background technique [0002] Citrus aurantium is the dry young fruit of Rutaceae plant lime (Citrus aurantium L.) and its cultivars or sweet orange (Citrussinensis Osbeck). The plant form is an evergreen small tree with long thorns. Alternate single leaves, leathery, petiole with narrow or obcordate wings; leaves oblong, with translucent oil spots; flowers arranged in racemes; calyx cup-shaped, 5-lobed; petals 5, white, oblong Shape; orange fruit round and slightly flattened, orange-yellow when ripe. The flowering period is April-May, and the fruiting period is June-November. Citrus aurantium is hemispherical, and a few are spherical, with a diameter of 0.5-2.5cm. The exocarp is black-green or dark brown-green, with granular protrusions and wrinkles, with obvious style remnants or fru...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/74G01N30/86
CPCG01N30/02G01N30/74G01N30/8679
Inventor 魏胜利张媛赵婷连天赐王昕怡王灵敏张燕玲张林胡秀华刘凤波
Owner 北京橘井健康科技集团有限公司
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