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Neuromodulation of glossopharyngeal nerves for improving sleep disorder breathing

A technique for neuromodulation and sleep disorders, applied in artificial respiration, application, treatment, etc., which can solve problems such as compliance rate restrictions

Pending Publication Date: 2022-05-27
VANDERBILT UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the success of CPAP therapy is limited by reported adherence rates ranging from 50% to 70%

Method used

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  • Neuromodulation of glossopharyngeal nerves for improving sleep disorder breathing
  • Neuromodulation of glossopharyngeal nerves for improving sleep disorder breathing
  • Neuromodulation of glossopharyngeal nerves for improving sleep disorder breathing

Examples

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Embodiment Construction

[0018] Provided herein is for amelioration in patients with SDB by delivering electrical neuromodulation signals to at least one target site including efferent fibers of the glossopharyngeal nerve (cranial nerve IX) innervating the pharyngeal constrictor or styloid pharyngeal muscles SDB method and system. Non-limiting examples of SDBs are increased upper airway resistance (including snoring), upper airway resistance syndrome (UARS), and sleep apnea. Sleep apnea includes OSA, central sleep apnea (CSA), and complex sleep apnea. As used herein in relation to the described elements, the terms "a," "an," and "the" include at least one or more of the described element(s) unless stated otherwise. Further, unless stated otherwise, the terms "or" and "and" refer to "and / or" and combinations thereof. The terms "first", "second", etc. are used to distinguish one element from another and are used in a quantitative sense unless stated otherwise. Thus, a "first" element described below ...

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Abstract

Methods and systems are provided for improving SDB in a patient suffering from SDB by delivering an electrical neuromodulation signal to at least one target site comprising outgoing fibers of glossopharyngeal nerves dominating pharyngeal contractile muscles or styloid pharyngeal muscles. The method also includes delivering the electrical neuromodulation signal to other sites including one or more combinations of the neck loop, hypoglossal nerve, palatolingual muscle, and / or palatopharyngeal muscle. The electrical neuromodulation signal delivered to the outgoing fibers of the glossopharyngeal nerve may be accomplished independently of a detected sensory or input signal that measures the neuromuscular state of the patient's airway.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Patent Application No. 62 / 900,442, filed September 13, 2019, and US Provisional Application No. 62 / 961,338, filed January 15, 2020. The contents of both applications are hereby incorporated by reference in their entirety. technical field [0003] The present disclosure relates to methods and systems for the treatment of sleep-disordered breathing by neuromodulating the efferent fibers of the glossopharyngeal nerve. Background technique [0004] Sleep-disordered breathing (sleep-disordered breathing, SDB) occurs when partial or complete cessation of breathing occurs multiple times throughout the night. Obstructive sleep apnea (OSA) is a type of SDB that involves a cessation or marked reduction of airflow in the presence of respiratory effort. This is the most common type of SDB and is characterized by recurrent episodes of upper airway collapse during sleep, causing re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36
CPCA61N1/3611A61N1/3601A61B5/4818A61B5/4836A61B5/087A61B5/024A61B5/021A61B5/389A61B5/388A61B5/0031A61N1/0551A61N1/36139A61N1/36175
Inventor 大卫·T·肯特
Owner VANDERBILT UNIV