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Trifluoromethyl oxadiazole compound, preparation method and application thereof, and bactericide

A technology of trifluoromethyl oxadiazoles and compounds, which is applied in the field of pesticides, can solve problems such as resistance problems, and achieve excellent control effects and good crop safety effects

Active Publication Date: 2022-05-31
JIANGSU FLAG CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a new class of trifluoromethyl oxadiazole compounds in order to overcome the resistance problem of existing fungicide targets

Method used

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  • Trifluoromethyl oxadiazole compound, preparation method and application thereof, and bactericide
  • Trifluoromethyl oxadiazole compound, preparation method and application thereof, and bactericide
  • Trifluoromethyl oxadiazole compound, preparation method and application thereof, and bactericide

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Experimental program
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specific Embodiment approach 1-1

[0035] According to the preferred embodiment 1-1 , in formula (I1),

[0036] R 1 , R 2 , R 3 , R 4 , R 5 each independently selected from any group in combination A, and R 1 , R2 , R 3 , R 4 , R 5 Not H at the same time,

[0037] Combination A consists of the following groups: H, fluorine, chlorine, bromine, iodine, C 1-8 Alkyl, C 1-8 Alkoxy, C substituted by at least one halogen 1-8 Alkyl, C substituted by at least one halogen 1-8 Alkoxyl, C 1-8 Alkyl-S(O) 2 -, C 2-8 Alkynyl, by C 3-5 Cycloalkyl-substituted C 5-8 Alkynyl, C substituted by at least one phenyl 7-16 alkoxy, nitro and morpholinyl.

specific Embodiment approach 1-2

[0038] According to the preferred embodiment 1-2 , in formula (I1),

[0039] R 1 , R 2 , R 3 , R 4 , R 5 Any 1-3 groups in are independently selected from any group in combination A except H, and R 1 , R 2 , R 3 , R 4 , R 5 The remaining groups in are H.

specific Embodiment approach 1-3

[0040] According to preferred embodiment 1-3 , in formula (I1),

[0041] R 1 , R 2 , R 3 , R 4 , R 5 Any 1-3 groups in are independently selected from any group in combination A except H, and R 1 , R 2 , R 3 , R 4 , R 5 The remaining group in is H;

[0042] Combination A consists of the following groups: H, fluorine, chlorine, bromine, iodine, C 1-6 Alkyl, C 1-6 Alkoxy, C substituted by at least one halogen 1-6 Alkyl, C substituted by at least one halogen 1-6 Alkoxyl, C 1-6 Alkyl-S(O) 2 -, C 2-6 Alkynyl, by C 3-5 Cycloalkyl-substituted C 5-8 Alkynyl, C substituted by at least one phenyl 7-16 alkoxy, nitro and morpholinyl.

[0043] According to particularly preferred embodiments 1-4 , the compound shown in formula (I1) is selected from any one of the following compounds:

[0044] Compound 1: Compound 2: Compound 3: Compound 4: Compound 5: Compound 6: Compound 7: Compound 8: Compound 9: Compound 10: Compound 11: Compound 12: Compou...

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Abstract

The invention relates to the field of pesticides, and discloses a trifluoromethyl oxadiazole compound, a preparation method and application thereof, and a bactericide, and the compound has a structure as shown in formula (I1). The trifluoromethyl oxadiazole compound provided by the invention can have an excellent control effect on at least one plant pathogenic microorganism of soybean rust, corn rust, cucumber anthracnose, cucumber downy mildew, cucumber powdery mildew, wheat brown rust and broad bean rust at a low dosage.

Description

technical field [0001] The invention relates to the field of pesticides, in particular to a trifluoromethyl oxadiazole compound, a preparation method and application thereof, and a fungicide. Background technique [0002] It has been reported in many documents that trifluoromethyl oxadiazole derivatives have the effect of preventing and controlling plant pathogenic microorganisms, especially fungi, such as WO2017 / 081309A1, WO2017 / 081310A1, WO2017 / 103219A1 and other prior art all involve trifluoromethyl oxadiazole derivatives Methyloxadiazole derivatives and their use in controlling plant pathogenic organisms. [0003] In terms of medical use, for example, WO2013 / 008162A1 describes trifluoromethyloxadiazole derivatives having HDAC4 inhibitory activity and their use in medicine. [0004] In addition, an article published by BASF in 2020 (DOI 10.1002 / ps.5874) has demonstrated that HDAC-targeted inhibitors have excellent control effects on rust. This shows that HDAC inhibitors...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D271/06A01N43/836A01P3/00
CPCC07D271/06A01N43/82Y02A50/30
Inventor 杨光富魏阁鲁强董姝妤张璞吴耀军赵文
Owner JIANGSU FLAG CHEM IND
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