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Inhibition of ZD17-JNK interaction as therapy for acute myocardial infarction

A technology for acute myocardial infarction and cardiomyocytes, applied in the fields of cardiovascular system diseases, chemical instruments and methods, retroRNA virus, etc.

Pending Publication Date: 2022-06-07
THE UNIV OF BRITISH COLUMBIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Despite the progress made so far in the development of cardioprotective treatments, there is still room for improvement in addressing the above-mentioned problems and shortcomings of existing technologies

Method used

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  • Inhibition of ZD17-JNK interaction as therapy for acute myocardial infarction
  • Inhibition of ZD17-JNK interaction as therapy for acute myocardial infarction
  • Inhibition of ZD17-JNK interaction as therapy for acute myocardial infarction

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experiment example

[0066] Embodiments of the present invention will be described with reference to the following exemplary information, which should not be used to limit or interpret the teachings described herein.

[0067] animal

[0068] Juvenile Sprague Dawley rats (P1-2) and adult male Sprague Dawley rats (180-220 g) were purchased from B&K Universal Ltd, China. Adult rats were housed in plastic cages with free access to food and water and maintained in a temperature-controlled room (22-25°C) with a light / dark cycle of 12 / 12 hours. All experimental protocols were approved by Second Military Medical University, and methods were performed in accordance with approved guidelines and regulations. Every effort was made to minimize animal suffering and reduce the number of animals used.

[0069] Chinese Bama miniature pigs (2-3 months; 7.81-10.43 Kg) were purchased from Wujiang Tianyu Biotech (Suzhou, China). Pigs were housed in stainless steel cages with free access to food and water and mainta...

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Abstract

Disclosed herein are uses of a polypeptide comprising NIMoEsh for treating a disease or condition associated with acute myocardial infarction (AMI) in a subject in need thereof, uses of a polypeptide comprising NIMoEsh for restoring cardiac function following AMI in a subject in need thereof, uses of a polypeptide comprising NIMoEsh for reducing or preventing loss of cardiac function caused by AMI in a subject in need thereof, and uses of a polypeptide comprising NIMoEsh for treating a disease or condition associated with AMI in a subject in need thereof. The present invention relates to the use of a polypeptide comprising NIMoEsh for reducing AMI-induced cardiac tissue infarction in a subject in need thereof, and the use of a polypeptide comprising NIMoEsh for protecting myocardial cells from AMI-induced dysfunction in a subject in need thereof. Also disclosed herein are methods for such treatment, recovery, reduction or prevention, reduction and / or protection, as well as polypeptides comprising NIMoEsh for such treatment, recovery, reduction or prevention, reduction and / or protection.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Patent Application Serial No. 62 / 899,440, filed on September 12, 2019. technical field [0003] The present disclosure relates generally to cardioprotection, and more particularly to the use of polypeptides to treat acute myocardial infarction. Background technique [0004] Acute myocardial infarction (AMI), commonly referred to as a heart attack, is a life-threatening cardiovascular disease. During an AMI, the blood supply to the heart is suddenly restricted due to a blocked coronary artery, which can cause serious damage to the heart. AMI kills more than 2.4 million people each year in the United States, more than 4 million in Europe and North Asia, and more than one-third of all deaths in developed countries. (Reed, G.W., Rossi, J.E. and Cannon, C.P. Acute myocardial infarction (Acutemyocardial infarction). Lancet 389, 197-210, doi: 10.1016 / S0140-6736(16)30677-8(20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K47/66A61P9/10C07K14/16C07K19/00C07K7/06
CPCA61P9/10A61K47/645C12N2740/16022C07K14/47C12N9/1029C07K2319/10A61K38/00A61K38/08
Inventor 杰克·吴洋·金王玉田马克思·S·希娜德尔
Owner THE UNIV OF BRITISH COLUMBIA
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