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Preparation method of scar gel containing yeast recombinant collagen

A technology for recombining collagen and yeast, applied in the field of medicine, can solve the problems of limited overall curative effect, difficult treatment, and affect the appearance, and achieve the effects of low immune rejection, significant effect, and easy absorption.

Pending Publication Date: 2022-07-05
湖南有美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Scars located on the face affect the appearance and are difficult to deal with. Although there are many clinical treatment options for scars, the overall curative effect is limited, and there are

Method used

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  • Preparation method of scar gel containing yeast recombinant collagen
  • Preparation method of scar gel containing yeast recombinant collagen
  • Preparation method of scar gel containing yeast recombinant collagen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of yeast recombinant collagen scar gel, comprising the following steps:

[0031] (1) Add 0.1 part of carbomer into purified water, place at room temperature for 6h, and fully swell;

[0032] (2) 3 parts of matrine, 3 parts of curcumin, 1 part of aloin, 1 part of glycyrrhizin, 1 part of laminarin, 1 part of shikonin, add 10 parts of 75% ethanol, stir until completely dissolved, Obtaining the traditional Chinese medicine monomer mixture;

[0033] (3) adding the prepared traditional Chinese medicine monomer mixture in step (2), 5 parts of yeast recombinant collagen, 1 part of emulsifier, 10 parts of glycerol, 20 parts of purified water, and 0.1 part of preservative to the swollen carbomer , stir evenly; then add 0.1 part of triethanolamine to adjust the pH to 6.0 to obtain a scar gel containing yeast recombinant collagen.

Embodiment 2

[0035] A preparation method of yeast recombinant collagen scar gel, comprising the following steps:

[0036] (1) 0.3 part of carbomer was added to purified water, placed at room temperature for 6h, and fully swollen;

[0037] (2) 5 parts of matrine, 5 parts of curcumin, 3 parts of aloin, 3 parts of glycyrrhizin, 3 parts of laminarin, 3 parts of shikonin, add 12 parts of 75% ethanol, stir until completely dissolved, Obtaining the traditional Chinese medicine monomer mixture;

[0038] (3) adding the prepared traditional Chinese medicine monomer mixture in step (2), 10 parts of yeast recombinant collagen, 2 parts of emulsifier, 12 parts of glycerol, 22 parts of purified water, and 0.2 part of preservative to the swollen carbomer , stir evenly; and then add 0.3 part of triethanolamine to adjust the pH to 6 to obtain a scar gel containing yeast recombinant collagen.

Embodiment 3

[0040] A preparation method of yeast recombinant collagen scar gel, comprising the following steps:

[0041] (1) 0.5 part of carbomer was added to purified water, placed at room temperature for 6h, and fully swollen;

[0042] (2) 7 parts of matrine, 7 parts of curcumin, 4 parts of aloin, 4 parts of glycyrrhizin, 4 parts of laminarin, 4 parts of shikonin, add 13 parts of 75% ethanol, stir until completely dissolved, Obtaining the traditional Chinese medicine monomer mixture;

[0043] (3) adding the prepared traditional Chinese medicine monomer mixture in step (2), 13 parts of yeast recombinant collagen, 3 parts of emulsifier, 13 parts of glycerol, 23 parts of purified water, and 0.2 part of preservative to the swollen carbomer , stir evenly; and then add 0.5 part of triethanolamine to adjust the pH to 6 to obtain a scar gel containing yeast recombinant collagen.

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Abstract

The invention discloses a preparation method of scar gel containing yeast recombinant collagen. The collagen mask is prepared from the following raw materials and auxiliary materials in parts by mass: 5 to 30 parts of yeast recombinant collagen, 3 to 15 parts of sophocarpidine, 3 to 14 parts of curcumin, 1 to 10 parts of barbaloin, 1 to 10 parts of ammonium glycyrrhizinate, 1 to 10 parts of laminarin, 1 to 10 parts of alkannin, 0.1 to 2 parts of carbomer, 0.1 to 1 part of triethanolamine, 1 to 10 parts of emulsifier, 0.1 to 0.5 part of preservative, 10 to 20 parts of glycerol, 10 to 20 parts of 75% ethanol and 20 to 30 parts of purified water. The traditional Chinese medicine composition contains various traditional Chinese medicine active ingredients, can achieve multi-component, multi-target and multi-path synergistic interaction, influences proliferation of fibroblasts, improves local microcirculation, influences secretion of growth factors, and promotes scar epidermis to recover a stable internal environment. Capillary hyperemia and collagenous fiber hyperplasia are relieved, and hyperplastic scars caused by trauma or operation are prevented and improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for preparing a scar gel containing yeast recombinant collagen. Background technique [0002] Scars are traces left after trauma involving the papillary dermis. They vary in size, depth and shape. Scars located on the face affect the appearance and are difficult to deal with. Although there are many clinical treatment options for scars, the overall curative effect is limited, and there are disadvantages such as large side effects and high cost. At present, there is no fully recognized method for the complete treatment of pathological scars in the world. Medicines, devices, methods, etc. Compared with clinical treatment programs, external gels have the advantages of being safe and effective for scar repair. [0003] Yeast recombinant collagen has a greater affinity for protein molecules on the skin surface, and is resistant, biodegradable and biocompatible. Since the yeast reco...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K47/10A61K47/32A61P17/02A61K9/06A61K31/12A61K31/122A61K31/351A61K31/4375A61K31/704A61K31/715
CPCA61K38/39A61K31/4375A61K31/12A61K31/351A61K31/704A61K31/715A61K31/122A61K47/32A61K47/10A61K9/06A61P17/02A61K2300/00
Inventor 戈欣蔡少红
Owner 湖南有美生物科技有限公司
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