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Novel gulcomannan heteroglycan peptide as well as preparation method and application thereof

A technology of heteroglycan and glucomannan, applied in the field of novel glucomannan heteroglycan peptide and its preparation, can solve the problems of easy scarring on the face and insignificant effect, achieve obvious skin moisturizing effect, avoid pore blockage, and eliminate The effect of redness

Pending Publication Date: 2022-07-05
四川奥邦投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are oral pharmaceutical preparations and topical medications to treat acne. Although these methods also have certain effects, they have serious disadvantages, such as ineffective effects, easy to leave scars on the face and other toxic side effects.

Method used

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  • Novel gulcomannan heteroglycan peptide as well as preparation method and application thereof
  • Novel gulcomannan heteroglycan peptide as well as preparation method and application thereof
  • Novel gulcomannan heteroglycan peptide as well as preparation method and application thereof

Examples

Experimental program
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Embodiment

[0028] A novel glucomannan peptide, the sugar chain repeating structural unit of the novel glucomannan peptide is as follows:

[0029]

[0030] The novel glucomannan peptide is the fermentation product of α-hemolytic streptococcus 33# (Streptococcus hemolyticus-a-Hemolysis). In terms of molar ratio, the monosaccharide composition of the novel glucomannan peptide is mannose. Sugar: rhamnose: glucose=8.22:1:6.46, its weight average molecular weight is 10045Da, and its molecular weight distribution coefficient is 1.31; its preparation method includes the following steps:

[0031] S1. Activate a-hemolytic streptococcus 33# (Streptococcus hemolyticus-a-Hemolysis) with blood plate, pick a single clone and inoculate it into a liquid medium to prepare a seed solution, pipette 5ml of the seed solution and inoculate it into 200ml of fermentation medium Cultivated at 37°C for 20 hours to obtain a fermentation broth, and fermented in batches according to this condition; the pH value of...

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PUM

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Abstract

The invention discloses a novel gulcomannan heteroglycan peptide and a preparation method and application thereof.The novel gulcomannan heteroglycan peptide is a fermentation product of alpha-hemolytic streptococcus 33 # and is separated and purified through a concentration and alcohol precipitation method and an ultrafiltration method to obtain uniform polysaccharide peptide, and the structure of the novel gulcomannan heteroglycan peptide is identified through physical and chemical analysis; the monosaccharide composition of the novel gulcomannan heteroglycan peptide comprises mannose, rhamnose and glucose in a molar ratio of 8.22: 1: 6.46, the weight-average molecular weight of the novel gulcomannan heteroglycan peptide is 10045Da, and the molecular weight distribution coefficient of the novel gulcomannan heteroglycan peptide is 1.31; when applied to acne-removing cosmetics, the acne-removing essence has an obvious moisturizing effect, is relatively long in moisturizing time, has an effect of inhibiting propionibacterium acnes in engine oil, achieves the effects of diminishing inflammation and removing acnes, and can balance sebum secretion on the surface of human skin, so that the repaired skin can be fuller, and the residue of acne marks is reduced; skin surface looseness and pore blockage can be avoided.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a novel glucomannan and a preparation method and application thereof. Background technique [0002] Cosmetics are necessities of people's daily life. At present, cosmetics on the market are divided into moisturizing, whitening, sun protection, acne removal, anti-wrinkle, etc. according to their functions; the active ingredients in cosmetics can be divided into synthetic and natural sources according to their sources. In recent years, the use of natural active ingredients in cosmetics has the advantages of clear effects and less toxic and side effects. [0003] Natural polysaccharides have complex biological activities and functions. Polysaccharides contain a large number of hydrophilic groups and exhibit excellent physical and chemical properties, such as strong water absorption, emulsification, high viscosity and good film-forming properties, which determine the natural advantages...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/315C12P21/00A61K8/64A61Q19/00C12R1/46
CPCC07K14/315C12P21/005A61K8/64A61Q19/00
Inventor 骆俊清苟小军
Owner 四川奥邦投资有限公司
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