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Application of SFRP4 as gastric cancer prognosis marker

A prognostic marker, 1.SFRP4 technology, applied in the field of tumor molecular biology, can solve the problem of unclear role of gastric cancer, and achieve the effect of good survival time

Pending Publication Date: 2022-07-08
ZHEJIANG CANCER HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that SFRP4 can act as a tumor suppressor and a tumor-promoting factor at the same time, and it plays completely opposite roles in different tumor types, but its role in gastric cancer is still unclear

Method used

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  • Application of SFRP4 as gastric cancer prognosis marker
  • Application of SFRP4 as gastric cancer prognosis marker
  • Application of SFRP4 as gastric cancer prognosis marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] 1. Method

[0103] 1.1. Patient and tissue microarray construction

[0104] A total of 137 patients with gastric cancer who were admitted to Cancer Hospital Affiliated to the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) from January 2013 to December 2017 were selected. Inclusion criteria: (1) The pathological diagnosis results of the samples were all gastric cancer; (2) No anti-tumor treatment such as chemoradiotherapy, biological therapy or immunotherapy was performed before surgery; (3) The medical records of the patients were complete. Exclusion criteria: (1) patients with other types of malignant tumors in the past; (2) patients with preoperative anti-tumor therapy; (3) patients with metastases from other tumor types.

[0105] Surgically resected gastric cancer tissue samples and adjacent tissue samples were collected from all patients, fixed in 4% paraformaldehyde, and embedded in paraffin. The tissue chip technology was used to construct ...

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Abstract

The invention discloses application of SFRP4 as a gastric cancer prognosis marker, belongs to the field of tumor molecular biology, and further discloses application of the SFRP4 as a treatment target in preparation of gastric cancer treatment drugs, expression up-regulation of the SFRP4 in gastric cancer tissues is remarkably related to poor prognosis; the SFRP4 is obviously related to abundance of various lymphocytes, immunomodulators and chemotactic factors in gastric cancer tissues, so that the survival time of a patient can be better predicted, even the state of an immune microenvironment can be evaluated, and the SFRP4 is a potential useful and reliable biomarker for guiding immunotherapy and determining prognosis of the gastric cancer patient. The invention also provides an application of the SFRP4 combined with CD8 + T as a gastric cancer prognosis marker, the gastric cancer prognosis can be better predicted by combining the SFRP4 combined with the CD8 + T, and the good prognosis of a patient is prompted by the low expression of the SFRP4 and the high infiltration of CD8 + T cells in a tissue sample.

Description

technical field [0001] The invention belongs to the field of tumor molecular biology, and particularly relates to the application of SFRP4 as a gastric cancer prognosis marker. Background technique [0002] According to estimates of cancer incidence and mortality from the International Agency for Research on Cancer, there will be 19.3 million new cancer cases and 10 million cancer deaths worldwide in 2020. Gastric cancer (GC) is the fifth most common malignancy worldwide and the fourth leading cause of cancer-related death. Although the diagnosis and treatment of gastric cancer have made progress in recent years, due to the mild early symptoms and low diagnosis rate, most patients are diagnosed with advanced gastric cancer, and the prognosis of gastric cancer is still unsatisfactory. The 5-year overall survival rate is less than 40%. . Therefore, it is particularly important to find effective biomarkers for early detection of gastric cancer and to develop new treatment str...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/569A61K45/00A61P35/00
CPCG01N33/57446G01N33/57484G01N33/56966A61K45/00A61P35/00G01N2333/47G01N2333/70517G01N2500/04
Inventor 程向东袁莉于鹏程徐志远胡灿
Owner ZHEJIANG CANCER HOSPITAL
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