Method for producing bacitracin D by fermenting diatomite immobilized bacillus

A technology of bacitramycin and Bacillus subtilis, applied in the direction of microorganism-based methods, biochemical equipment and methods, immobilized on or in inorganic carriers, etc., can solve the problems of not fixing Bacillus subtilis, etc., and achieve easy operation Effect
CN114774498APending Publication Date: 2022-07-22NANJING UNIV OF FINANCE & ECONOMICS
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF FINANCE & ECONOMICS
Publication Date
2022-07-22

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Abstract

The invention discloses a method for producing bacitracin D by fermenting diatomite immobilized bacillus, and belongs to the technical field of biology. According to the method, diatomite is added in the fermentation process of bacillus subtilis fmbJ (CGMCC No.0943) to perform immobilized fermentation on the fmbJ, so that the yield of the secondary metabolite bacitracin D of the bacillus subtilis can be remarkably increased, repeated fermentation can be performed under the condition of not adding any fresh seed solution, and the yield of the bacitracin D is remarkably increased. According to the method, the yield of bacitracin D is increased, the utilization rate of the raw materials is also increased, the production cost is reduced, and a by-product (diatomite adsorbing bacillus subtilis) obtained after fermentation can also be used for preparing a microbial preparation and can be applied to grain storage, fruit and vegetable preservation and animal feed.
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Description

1. Technical field

[0001] The invention relates to the field of microbial fermentation, in particular to a method for fermenting bacillus immobilized with diatomaceous earth to produce bacillimycin D. 2. Background technology

[0002] With the rapid development of social economy, people pay more and more attention to green environmental protection and health. The extensive use of chemical fungicides leads to the problem of chemical residues, which will not only aggravate environmental pollution, but also seriously endanger human health. At present, the world is urgently seeking a new alternative to chemical fungicides. Bacillus subtilis (Bacillus subtilis) fmbJ is a Gram-positive bacterium belonging to the genus Bacillus, which can secrete a series of antibacterial lipopeptides such as bacteromycin D, fengycin, and surfactin. Using its metabolite antibacterial lipopeptide as a substitute for chemical fungicides, bacillomycin D has a strong inhibitory effect on a variety of...

Claims

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