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Application of nitixinone in preparation of medicine for preventing and treating endotoxic shock diseases

A technology of nitisinone and endotoxin, applied in the field of biomedicine, to achieve the effect of improving survival rate and broadening the scope of application

Pending Publication Date: 2022-08-02
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of endotoxemia / shock mainly adopts comprehensive measures, and there is no specific drug

Method used

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  • Application of nitixinone in preparation of medicine for preventing and treating endotoxic shock diseases
  • Application of nitixinone in preparation of medicine for preventing and treating endotoxic shock diseases
  • Application of nitixinone in preparation of medicine for preventing and treating endotoxic shock diseases

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Embodiment Construction

[0018] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, so as to better understand the present invention, but the following embodiments do not limit the scope of the present invention.

[0019] In the examples, if there are no special instructions, conventional methods are used, and if there are no special instructions, the reagents used are conventional commercially available reagents or reagents prepared by conventional methods.

[0020] (1) Experimental materials

[0021] Preparation of Nitisinone: dissolve 10 mg of Nitisinone with 30.37 uL DMSO, the molar concentration is 1 M, and the mass-volume ratio is 329.23 mg / mL. Take 1uL of the above solution and add 999uL of double-distilled water, dilute 1000 times, the molar concentration is 1mM, and the mass-volume ratio is 329.23ug / mL. Take 15uL of the Nitisinone solution and add 2.485mL of double-distilled water, and dilute it by 164.6 time...

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Abstract

The invention discloses application of nitixinone in preparation of a medicine for preventing and treating endotoxic shock diseases, and belongs to the field of biological medicines. Animal experiments prove that the nitixinone can improve the survival rate of endotoxin shock mice by inhibiting secretion of inflammatory cytokines IL-1b, IL-6 and TNF-alpha and chemotactic factors MCP-1 and the like caused by LPS exposure, so that the nitixinone has a potential value of being developed into a new generation of new-generation medicines for preventing and treating endotoxin shock, and has a wide application prospect. And a new way is provided for prevention and treatment of endotoxin shock.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of nitisinone in the preparation of drugs for preventing and treating endotoxic shock diseases. Background technique [0002] Nitisinone, English name: Nitisinone, chemical name: 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, English alias: 2-[2-nitro -4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione, 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, NTBC, etc.; Molecular formula: C 14 H 10 F 3 NO 5 ; Molecular weight: 329.23, the chemical structure is as follows: Nitisinone is a reversible inhibitor of 4-hydroxyphenylpyruvate oxidase (dioxygenase), currently mainly used for the treatment of type 1 hereditary tyrosinemia, can prevent the toxic process of tyrosine metabolism Accumulation of substances Maleylacetoacetate, Fumarylacetoacetate, etc. [0003] Sepsis, endotoxemia and shock caused by bacterial infection are the common causes of deat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P31/04A61P29/00
CPCA61K31/122A61P31/04A61P29/00Y02A50/30
Inventor 韦艳霞王玉刚刘梦楠布会敏刘佃滨寇艳波刘转转
Owner XUZHOU MEDICAL UNIV
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