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Fibrauretine slow releasing preparation

A technology of patulin and sustained-release tablets, applied in respiratory system diseases, urinary system diseases, sexual diseases and other directions, can solve the problems of blind spots in treatment, troublesome patients taking, easy to miss the interval of taking medicine at night, etc., and achieve good stability. , the effect of reducing the number of doses and the number of tablets

Inactive Publication Date: 2005-09-07
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The number of daily oral administration of Huanggensu Tablets is relatively large, the dose is relatively large, and it is troublesome for patients to take, and it is easy to miss doses and take too long intervals at night to maintain effective blood drug concentrations and exert continuous therapeutic effects. blind spot

Method used

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  • Fibrauretine slow releasing preparation
  • Fibrauretine slow releasing preparation
  • Fibrauretine slow releasing preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] [Ingredient] Palmatine 300mg

[0062] HPMC (K4M) 150mg

[0063] Lactose 100mg

[0064] Magnesium Stearate 6mg

[0065] [Preparation method] Mix palmatine with HPMC and lactose, dissolve in ethanol as a wetting agent to make a soft material, granulate, dry, granulate, add magnesium stearate, mix evenly, and press into tablets to obtain palmetine Sustained Release Tablets.

Embodiment 2

[0067] [Ingredient] Palmatine 400mg

[0068] Hypromellose 80mg

[0069] Dextrin 20mg

[0070] Sodium Lauryl Sulfate Appropriate amount

[0071] Proper amount of ethanol

[0072] Magnesium Stearate Appropriate amount

[0073] [Preparation method] Mix palmatine with sodium lauryl sulfate, hypromellose, and dextrin to make a soft material, granulate with a 20-mesh sieve, dry, granulate with a 18-mesh granule, add magnesium stearate and mix Mix evenly, and press into tablets to obtain palmatine sustained-release tablets.

Embodiment 3

[0075] [Ingredient] Palmatine 300mg

[0076] Sodium Alginate 180mg

[0077] Calcium Chloride Anhydrous 20mg

[0078] Magnesium Stearate 5mg

[0079] [Preparation method] Mix palmatine, sodium alginate and anhydrous calcium chloride evenly, add 2% sodium alginate slurry to granulate, dry, add magnesium stearate, mix evenly, granulate, and tablet to obtain yellow Rattan Sustained Release Tablets.

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Abstract

The slow releasing fibrauretine preparation consists of fibrauretine in 40-70 wt%, slow releasing supplementary material in 10-30 wt% and other supplementary material. The preparation may be skeleton type, membrane cavity type, porous matrix type, penetrating pump type, slow releasing microcapsule type, slow releasing microballoon type, or slow releasing pellet type. The preparation of the present invention has prolonged acting period, and thus reduced medicine taking times, lowered medicine side effect and raised medicine adaptability.

Description

technical field [0001] The present invention relates to a composition containing palmetine, more specifically, the present invention relates to a sustained-release preparation of palmetine. Background technique [0002] Palmatine hydrochloride is an alkaloid palmatine hydrochloride derived from the stem of Fibraurea tinctoria Lour. Lutein is yellow needle-like crystal; odorless, very bitter taste. Easily soluble in hot water, slightly soluble in ethanol or chloroform, insoluble in ether. Palmatine has the function of clearing heat and detoxifying, and is used for gynecological inflammation, bacillary dysentery, enteritis, respiratory tract and urinary tract infection, surgical infection, conjunctivitis, etc. Because of its wide antibacterial spectrum, definite curative effect, and less toxic and side effects, it has been widely used clinically. At present, the domestically developed Huangtengsu preparations include Huangtengsu Injection, Huan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/22A61K31/14A61P11/00A61P13/02A61P15/00A61P27/02A61P31/04
Inventor 廖晓春梅艳胡炜颜
Owner YUNNAN PHYTOPHARML
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