Uncaria slow release capsule preparation and preparation method thereof

A technology for sustained-release capsules and preparations, which is applied in the field of Uncaria sustained-release capsule preparations and preparations thereof, and can solve the problems of unfavorable storage of decoctions, lack of sustained-release effects, and inability to control blood pressure stably.

Inactive Publication Date: 2010-10-27
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, total alkaloids of Uncaria can be used to treat hypertension, but Chinese herbal medicines are usually decocted into decoctions, but decoctions a

Method used

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  • Uncaria slow release capsule preparation and preparation method thereof
  • Uncaria slow release capsule preparation and preparation method thereof
  • Uncaria slow release capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: First take by weighing 67g starch, 33g sodium carboxymethyl cellulose, 33g soluble starch, 67g dextrin, 33g calcium hydrogen phosphate respectively pass through 100 mesh sieve, mix evenly, with 5% (w / v) polyvinylpyrrolidone 35% ethanol solution was used as a wetting agent, and the ball core was made into a coating granulator, and dried at 40°C for 7 hours to obtain a blank ball core. Then weigh 3.75 g of rhynchophylline, 26 g of dextrin, and 0.5 g of sodium dodecylsulfonate and pulverize them through a 100-mesh sieve, and place the blank ball core in a coating pan at a speed of 100 rpm. Add the mixture of rhynchophylline, dextrin and sodium dodecylsulfonate, spray into 90% ethanol solution of 10% polyvinylpyrrolidone, then add the powder mixture, spray into the solution, and repeat the operation until all the powder is added. After dosing, take it out, place it in a tray, and dry it overnight at 50-65°C. Finally, 17 g of hydroxypropyl methylcellulose was ...

Embodiment 2

[0064] Embodiment 2: First take by weighing 130g starch, 20g methylcellulose, 100g dextrin, cross 100 mesh sieves, mix evenly, to contain 15% (W / V) polyvinylpyrrolidone and hydroxypropyl methylcellulose (1 : 1) 50% ethanol solution of the mixture is used as a wetting agent, and a blank pellet core is made in a coating granulator, dried at 60° C. for 3 hours, and set aside. Then weighed 37.5 g of total alkaloids of Uncaria uncariae, 20 g of starch, and 1.0 g of sodium lauryl sulfate, respectively pulverized them through a 100-mesh sieve, and placed blank ball cores in a coating pan at a speed of 50 rpm. Add the mixture of Uncaria total alkaloids, starch and sodium lauryl sulfate, spray 50% ethanol solution of 15% polyvinylpyrrolidone and hydroxypropyl methylcellulose (1:1), then add the powder mixture, spray Add the solution and repeat the operation until all the powders are added. After adding the medicine, take it out, place it in a tray, and dry it at 50-80°C. Finally, 15 ...

Embodiment 3

[0065]Embodiment 3: first take by weighing 85g starch, 50g microcrystalline cellulose, 88g dextrin, sieve, mix uniformly, with 10g ethyl cellulose as wetting agent, make blank ball core in coating granulator, Dry and set aside. Then weigh 6.5g of rhynchophylline, 43g of starch, and 1.0g of sodium lauryl sulfate to pulverize and sieve respectively, place the blank ball core in the coating pan, add the mixture of rhynchophylline, starch and sodium lauryl sulfate The mixture is sprayed with ethyl cellulose, then the powder mixture is added, the ethyl cellulose is sprayed, and the operation is repeated until all the powders are added. After dosing, take it out and place it on a tray to dry. Finally, 5 g of hydroxypropyl methylcellulose was weighed and added to 200 ml of 70% ethanol, and left overnight. Add 15 g of diethyl phthalate and 1.0 g of titanium dioxide, and stir evenly to make a coating liquid. Put the above-mentioned vegetarian pills in the coating pot, then spray the...

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Abstract

The invention discloses an uncaria slow release capsule preparation and a preparation method thereof. The preparation is prepared from 1 to 15 parts by weight of uncarine or uncaria rhomotoxine and 73.2 to 130.2 parts by weight of accessories, wherein the accessories comprise 65 to 85 parts of excipient, 3 to 15 parts of coating agent, 5 to 20 parts of wetting agent, 0.1 to 0.5 part of surface active agent, 0 to 9 parts of plasticizer and 0.1 to 0.7 part of sunscreen. Compared with the prior art, by a slow release technology of the invention, medicaments are slowly released; the fluctuation of the concentration of plasma medicaments is effectively reduced; a peak valley phenomenon caused by frequent administration of an ordinary preparation is avoided; the utilization rate of the medicaments is enhanced; the medical cost is reduced; and the direct stimulation of the medicaments for the gastrointestinal tract is reduced. Therefore, side effects are reduced; patients are easy to endure the medicaments; and the preparation is beneficial to long-term treatment and hypertensive treatment. In addition, the invention also simplifies the technology; the preparation process of a capsule is easier to operate and more convenient to carry and take; the problem of the prior art is solved; and the purpose of the invention is achieved.

Description

technical field [0001] The invention relates to an Uncaria sustained-release capsule preparation and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Hypertension belongs to the pain syndromes of dizziness, headache, liver yang and liver wind in traditional Chinese medicine. The main symptoms of the patient are dizziness, headache and elevated blood pressure. It can be caused by the imbalance of liver and kidney yin and yang due to heredity or long-term mental stress, depression, or addiction to fat, sweet, and excessive drinking. In severe cases, symptoms such as stroke and coma may occur. Hypertension is a common disease and the most important risk factor for major diseases such as coronary heart disease and cerebrovascular disease that lead to human death. The morbidity and mortality of cardiovascular and cerebrovascular diseases are closely related to the blood pressure level of patients. Therefore, all countrie...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/437A61K36/74A61P9/12
Inventor 黄文荣周方勇李江
Owner GUIZHOU BAIHUA PHARMA
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