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Nano magnetic heating seed for thermotherapy, its preparation method and use

A nano-magnetic and nano-magnetic powder technology, which is applied in the field of magnetothermal seeds for hyperthermia treatment of tumors and its preparation, can solve the problems of uncomfortable muscles, large particle size of magnetic materials, and easy agglomeration

Inactive Publication Date: 2006-02-22
南京伍盛纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the magnetic thermal seeds used in the thermal therapy of magnetic thermal seeds are all magnetic materials above the micron level. Due to the large particle size of the magnetic materials, they are easy to agglomerate and are not suitable for injection into blood vessels, muscles, etc., nor can they be taken orally. They are only suitable for embedded There are two ways of using it: injection and injection into the tumor site, and there are limitations in the scope of application and therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1. Preparation of Nano Magnetocaloric Seeds for Hyperthermia

[0010] Weigh 100g of nano-magnetic powder with a particle size of 5-10nm, sterilize with sprinkling, and add it to 402g aqueous solution containing 2g of surfactant sodium hexametaphosphate. The weight ratio of nano-magnetic powder: surfactant: water is 1 :0.02:4, then use ultrasonic or stirring to make the nanometer magnetic powder fully dispersed and uniform, after centrifugal separation, remove the supernatant, then wash with water to remove the excess surfactant, use vacuum drying to make the powdered solid nanometer for hyperthermia Magnetocaloric seeds.

Embodiment 2

[0011] Example 2. Preparation of nano-magnetocaloric seeds for hyperthermia without surfactants.

[0012] Weigh 100g of nano-magnetic powder with a particle size of 50-100nm, sterilize at high temperature, and mix it into 2000g of pure water. The weight ratio of nano-magnetic powder: water is 1:20, and then use ultrasonic to make the nano-magnetic powder evenly dispersed. It becomes a nano-magneto-caloric seed water for injection and hyperthermia.

Embodiment 3

[0013] Example 3. Preparation of Nano Magnetocaloric Seed Water for Hyperthermia

[0014] Weigh 100g of magnetic powder with a particle size of 20-40nm, after high temperature sterilization, add 5g of surfactant cetyldimethylammonium bromide, add it to 50g of pure water, weight of nano magnetic powder: surfactant: water The ratio is 1:0.05:0.5. It is fully dispersed by grinding or ultrasonic to form a colloid. After sedimentation, the supernatant is removed. The excess surfactant cetyldimethylammonium bromide is washed with pure water, and then physiological saline is added. 2000g is fully dispersed to prepare a nano-magnetic thermal seed water for hyperthermia.

[0015] The nano-magnetic powder used in the above embodiments can be nano-ferromagnetic magnetic powder, nano-ferromagnetic magnetic powder and nano-superparamagnetic magnetic powder.

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PUM

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Abstract

A magnetothermal nanometer seed for thermotherapy to tumor is prepared from nanometre magentic particles, surfactant and purified water in Wt ratio of 1:(0-0.05):(0.5-20) through fully mixing to obtain a colloid or suspension, washing with purified water to remove excessive surfactant, and adding aqueous solution, to obtain the injection, or drying to obtain the powder.

Description

Technical field [0001] The nano-magnetic thermal seed for hyperthermia and its preparation method and application of the present invention relate to a magnetic-caloric seed for hyperthermia and treatment of tumors made of nano-magnetic powder as the main component and its preparation method and application. Background technique [0002] Magnetocaloric seed hyperthermia is a method of hyperthermia that uses the hysteresis thermogenesis effect of the magnetocaloric seed in the tumor site to heat the tumor, selectively kill the tumor cells and treat the tumor. Compared with other extracorporeal hyperthermia methods, it has outstanding advantages such as accurate temperature control, precise positioning, no damage to normal tissues around the tumor, safety and reliability, and has become an effective method for tumor treatment. However, the current magnetocaloric seeds used in magnetocaloric seed hyperthermia are all magnetic materials above micrometer level. Due to the large particl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N2/10A61B18/04A61F7/00A61J3/00
Inventor 朱宏
Owner 南京伍盛纳米科技有限公司