Adherence peptide specific to tissue of liver cancer obtained through sieve method in rivo and usage
A liver cancer tissue-specific technology, applied in the field of targeting peptides, can solve problems such as side effects, and achieve the effects of good targeting effect, strong tissue distribution specificity, and broad application prospects.
Inactive Publication Date: 2006-05-31
EAST CHINA NORMAL UNIV
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Currently, the methods used for the treatment of liver cancer mainly include surgical therapy, radiotherapy and chemotherapy, etc., but these methods have different degrees of side effects on healthy tissues and organs of the human body.
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[0014] Before describing the specific embodiment, the configuration of materials and reagents and reagents to be used in the present invention are briefly explained:
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Abstract
An adhesion peptide capable of specifically binding liver cancer tissues / cells in tumor-guided therapy and the application of the adhesion peptide belong to the technical field of molecular pharmacology. The polypeptide sequences of the adhesion peptides of the three liver cancer tissues / cells provided by the present invention are: Sequence 1: NH 2 -A-G-K-G-T-P-S-L-E-T-T-P-COOH, sequence two: NH 2 -A-H-Q-A-N-F-P-S-S-S-A-I-COOH and sequence three: NH 2 -T-P-R-A-E-L-H-F-G-Q-S-S-COOH, the liver cancer tissue / cell-specific adhesion peptide has good targeting effect and strong tissue distribution specificity, and has broad application prospects in the preparation of targeting drugs for liver cancer.
Description
technical field [0001] The present invention relates to a targeting peptide in tumor-guiding therapy and the application of the targeting peptide, in particular to an adhesion peptide capable of specifically binding liver cancer tissues / cells and the application of the adhesion peptide, which belongs to the technical field of molecular pharmacology . technical background [0002] Liver cancer, as one of the most common malignant tumors, poses a great threat to human health. It is estimated that 1.25 million patients die of liver cancer every year in the world. The methods currently used for the treatment of liver cancer mainly include surgical therapy, radiotherapy and chemotherapy, etc., but these methods have different degrees of side effects on healthy tissues and organs of the human body. [0003] Guided therapy technology has opened up broad prospects for the treatment of tumors. Tumor-directed therapy refers to the application of monoclonal an...
Claims
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IPC IPC(8): C07K7/08A61K38/10A61P35/00
Inventor 钱旻周忠良章平杜冰于静郁萌
Owner EAST CHINA NORMAL UNIV