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Multifunctional depot type medicine carrier and preparation method thereof

A storage dosage form and multifunctional technology, applied in the field of surgical implant biomedical drug carriers, can solve problems such as adverse reactions and blood drug fluctuations, and achieve the effects of reducing side effects, easy molding, and easy mechanized mass production

Inactive Publication Date: 2006-07-05
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional drug delivery methods are used for drugs that are effective but have large side effects. While the drugs are being absorbed through the mucosa, intestinal tract or treated through intravenous injection, the drugs are also transmitted and diffused to other parts of the body. Cause blood fluctuations in the human body and adverse reactions caused by side effects, bringing new pain to patients

Method used

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Effect test

preparation example Construction

[0024] The preparation method of the multifunctional storage dosage form drug carrier is as follows:

[0025] 1. Raw materials of composite materials:

[0026] The invention uses poly D, L lactic acid and apatite as raw materials of the composite material. Poly D, L lactic acid adopts ring-opening polymerization method to obtain polylactic acid with a molecular weight of 100,000 to 500,000 and process it into thin slices of about 0.05 to 0.1 mm; apatite adopts methods such as precipitation method, wet method, solid phase calcination or hydrothermal synthesis. Preparation, drying and jet crushing to obtain apatite with a particle size of about 15-85 μm.

[0027] 2. Preparation of composite materials:

[0028] Choose to account for 70~95wt% of composite material total weight, molecular weight is 10~500,000 poly D, L lactic acid and account for 5~30wt% of composite material total weight, particle diameter is 15~85 μ m apatite (apatite is Hydroxyapatite, tricalcium phosphate an...

example 1

[0039] (1) Preparation of composite material: Add 2 g of uniformly mixed apatite (that is, a mixture of 1.5 g of hydroxyapatite with a particle size of 30 to 60 μm and 0.5 g of tricalcium phosphate) in 50 ml of absolute ethanol, and after 10 to 20 minutes After ultrasonic dispersion, add 10g of sheet-like poly D, L lactic acid with a molecular weight of 200,000 and 0.05-0.1mm for adsorption, take it out to dry naturally or in vacuum, and then mix it in a kneader for 2-5 minutes to prepare composite material.

[0040] (2) Add 12g of the composite material in (1) above to 30ml of analytically pure acetone solution, stir at room temperature until uniform, then add 50g of 20-300μm salt (NaCl), and continue stirring until dry and viscous, then pack Put it into the storage dosage form mold, mold it with a pressure less than 2Mpa, take out the finalized storage dosage form drug carrier, and let the solvent completely volatilize through natural or vacuum drying.

[0041] (2) Immerse th...

example 2

[0044] (1) Preparation of composite material: Add 2 g of uniformly mixed apatite (that is, a mixture of 1.5 g of hydroxyapatite with a particle size of 30 to 60 μm and 0.5 g of tricalcium phosphate) in 50 ml of absolute ethanol, and after 10 to 20 minutes After ultrasonic dispersion, add 10g of sheet-like poly D, L lactic acid with a molecular weight of 200,000 for adsorption, take it out to dry naturally or in vacuum, and then mix it in a kneader for 2 to 5 minutes to prepare a composite material.

[0045] (2) Add 12g of the composite material described in (1) above to 30ml of analytically pure ethyl acetate solution, stir at room temperature until uniform, then add 36g of chemically pure ammonium bicarbonate, and continue stirring until dry and viscous, Put it into a mold and mold it, and then take out the shaped drug carrier after demoulding, and let the solvent evaporate completely through natural or vacuum drying.

[0046] (2) Immerse the dried drug carrier in deionized w...

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Abstract

The invention relates to a multifunctional depot type medicine carrier and preparation method, wherein the multifunctional depot type medicine carrier comprises poly D, L lactic acid and phosphorite, the poly D, L lactic acid has a molecular weight of 100-500 thousand, and a thickness of 0.05-0.1 mm, whose weight accounts to 70-95% of the total weight, the grain size of the phosphorite is 15-85 um, whose weight accounts to 5-30% of the total weight, the bore diameter of the medicament carrier is 10-500 um.

Description

technical field [0001] The invention belongs to the technical field of surgically implantable biomedical drug carriers, and in particular relates to a multifunctional storage-type drug carrier and a preparation method thereof. Background technique [0002] In our country with a large population, human bone diseases such as bone tuberculosis, bone tumor, and bone infection caused by various reasons are frequently-occurring diseases. In the treatment, surgical resection of lesions is usually combined with traditional oral and intravenous injections. Prevent the spread and infection of postoperative lesions. However, traditional drug delivery methods are used for drugs that are effective but have large side effects. While the drug is being absorbed through the mucosa, intestinal tract or intravenously injected for treatment, the drug is also transmitted and diffused to other parts of the body. Cause fluctuations in human blood medicine and adverse reactions caused by side effe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34
Inventor 万涛李世普陈晓明闫玉华李建华贺建华王振林
Owner WUHAN UNIV OF TECH
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