Combination therapy comprising amlodipine and a statin compound

A technology of amlodipine and statin, applied in the field of pharmaceutical compositions, can solve problems such as inability to normalize cardiovascular mortality

Inactive Publication Date: 2000-09-27
PFIZER PRODS ETAT DE CONNECTICUT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, it has been demonstrated that attempts at hypertension interventi

Method used

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Embodiment Construction

[0143] The compound of the present invention contains two active ingredients: amlodipine or its pharmaceutically acceptable acid addition salt and statin or its pharmaceutically acceptable salt. The compound of the present invention may also contain a pharmaceutically acceptable carrier or diluent.

[0144] Amlodipine is a potent calcium channel blocker used in the treatment of high blood pressure. Amlodipine can be prepared as described in US Patent 4,572,909, which is incorporated herein by reference. Currently Norvasc  Amlodipine besylate, marketed under the name Amlodipine besylate, may be prepared as described in US Patent 4,879,303, which is incorporated herein by reference. Amlodipine, amlodipine besylate and other pharmaceutically acceptable acid addition salts of amlodipine are potent long-acting calcium channel blockers. Other acid addition salts of amlodipine can be prepared by reacting the free base of amlodipine with a suitable acid. When the salt is a salt o...

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Abstract

This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and statins or pharmaceutically acceptable salts thereof, kits containing such combinations and methods of using such combinations to treat subjects suffering from angina pectoris, atherosclerosis, combined hypertension and hyperlipidemia and to treat subjects presenting with symptoms of cardiac risk, including humans. This invention also relates to additive and synergistic combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and statins or pharmaceutically acceptable salts thereof whereby those additive and synergistic combinations are useful in treating subjects suffering from angina pectoris, atherosclerosis, combined hypertension and hyperlipidemia and those subjects presenting with symptoms of cardiac risk, including humans.

Description

[0001] The present invention relates to a pharmaceutical compound of amlodipine or its pharmaceutically acceptable acid addition salt, statin and its pharmaceutically acceptable salt, a kit containing said compound and using said compound to treat angina pectoris, atherosclerosis, Method for treating individuals with mixed hypertension and hyperlipidemia and individuals with cardiac risk symptoms, including humans. The present invention also relates to a compound with additive and synergistic effects of amlodipine or a pharmaceutically acceptable acid addition salt thereof and a statin compound or a pharmaceutically acceptable salt thereof, so that the compound with additive and synergistic effects can be used for the treatment of Individuals with angina pectoris, atherosclerosis, mixed hypertension, and hyperlipidemia, and individuals, including humans, with symptoms or signs of cardiac risk are treated. Background of the invention [0002] The conversion o...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/455A61K31/225A61K31/366A61K31/40A61K31/44A61K31/4422A61K39/39A61K45/06A61K47/26A61K47/40A61P3/06A61P7/02A61P9/10A61P9/12A61P37/04A61P43/00
CPCA61K31/366A61K2039/55577A61K31/455A61K47/26A61K31/225A61K31/40A61K47/40A61K31/44A61K45/06A61P11/06A61P3/06A61P37/04A61P43/00A61P7/02A61P9/00A61P9/10A61P9/12A61K2300/00
Inventor J·巴克R·A·D·斯科特
Owner PFIZER PRODS ETAT DE CONNECTICUT
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