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Pharmaceutical composition for intramuscular injection containing loxoprofen

A composition and injection technology, applied in the field of intramuscular injection preparations, can solve problems such as shedding, patch not fully developed, restricted movement discomfort, etc.

Inactive Publication Date: 2006-10-11
SHIN POONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patches have not been fully developed in a large number of studies
In addition, transdermal formulations of loxoprofen must contain many adjuvants such as penetration enhancers, and thus can introduce side effects such as skin rashes
In addition, they can cause discomfort that restricts movement due to being glued to one part of the body for a long time
Specifically, since inflammation or pain may occur at joints, transdermally absorbed patches may have many problems in continuously providing expected pharmacological effects, for example, because they are easily peeled off from the skin due to joint motion

Method used

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  • Pharmaceutical composition for intramuscular injection containing loxoprofen
  • Pharmaceutical composition for intramuscular injection containing loxoprofen
  • Pharmaceutical composition for intramuscular injection containing loxoprofen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve loxoprofen sodium and sodium metabisulfite in distilled water for injection. The solution was sterilized at high temperature under vacuum and filled into 1 mL ampoules for intramuscular injection (Table 1).

[0025] components

Embodiment 2

[0027] Loxoprofen sodium and sodium metabisulfite were dissolved in distilled water for injection. Dilute hydrochloric acid was added thereto to adjust the pH to 6. The resulting solution was sterilized at elevated temperature under vacuum or by sterile filtration and filled into 1 mL ampoules to give intramuscular injection (Table 2).

[0028] components

Embodiment 3

[0030] Loxoprofen sodium and sodium metabisulfite were dissolved in distilled water for injection. Dilute hydrochloric acid was added thereto to adjust the pH to 5. The resulting solution was sterilized at elevated temperature under vacuum or by sterile filtration and filled into 1 mL ampoules to give intramuscular injection (Table 3).

[0031] components

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PUM

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Abstract

The invention discloses an intramuscular injection preparation containing loxoprofen or a pharmaceutically acceptable salt thereof as an active ingredient, which has excellent anti-inflammatory and analgesic effects.

Description

technical field [0001] The invention relates to a new pharmaceutical preparation containing loxoprofen. Specifically, the present invention relates to a preparation for intramuscular injection containing loxoprofen or a pharmaceutically acceptable salt thereof as an active ingredient, which has excellent anti-inflammatory and analgesic effects. Background technique [0002] Loxoprofen (chemical name: 2-[4-(2-oxocyclopentane)phenyl]propionic acid) is a propionic acid non-steroidal anti-inflammatory drug (NSAID) and is represented by the following formula: [0003] [0004] The above drugs are generally available in the form of the sodium salt, that is to say loxoprofen sodium. [0005] Loxoprofen sodium is effective in the treatment of rheumatoid arthritis, osteoarthritis, lumbosacral strain, adhesive bursitis, and shoulder-brachial-neck syndrome. The drug is also known to be effective in reducing postoperative or post-traumatic pain, or for analg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61P29/00A61K9/00A61K9/19A61K31/19A61K31/192A61K47/02A61K47/04A61K47/12
CPCA61K9/0019A61K31/192A61K47/02A61P29/00A61K9/08
Inventor 李星泰韩信朴雨逸李哲规金惠善
Owner SHIN POONG PHARMA CO LTD