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Method for treating cancer with curcumin plus catechin

A technology of malignant tumors and catechins, which is applied in antineoplastic drugs, pharmaceutical formulations, organic active ingredients, etc.

Inactive Publication Date: 2002-10-30
NAN FANG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] There are many methods currently used to treat malignant tumors. Curcumin is a phenolic pigment extracted from the rhizome turmeric of Zingiberaceae. It is mainly used as a natural food coloring and incense in the folk; catechin is the main ingredient in green tea. It is reported that green tea has anti-tumor effect, but the method of using curcumin-catechin to treat malignant tumors has not been recorded in the world at present.

Method used

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Embodiment Construction

[0006] A curcumin-catechin method for treating malignant tumors, characterized in that: (a) extract curcumin from the rhizome of turmeric to inhibit the growth of colorectal cancer cell LoVo; (b) extract catechin from green tea (four main components: EGCE, EGC, ECG and EC), induce LoVo cell apoptosis and affect its growth cycle. Curcumin interferes with the cell cycle of colorectal cancer cells, making S and G cells that are blocked in the cell cycle 2 +M phase, thereby inducing apoptosis. The mechanism by which catechin induces LoVo cell apoptosis is mainly by activating the sphingomyelin cycle on the cell, causing the hydrolysis of sphingomyelin to produce ceramide, down-regulating the expression level of various protein kinase C isozymes and regulating oncogenes The protein expression levels of Bcl-2 and Bax were achieved. When used, because curcumin has a strong anti-colorectal cancer effect, it can inhibit the growth of colorectal cancer cells LOVO in vitro, and interfe...

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Abstract

A method for treating cancer with curcumin and catechin features that said curcumin extracted from turmeric can suppress the growth of intestinal cancer cells (LoVo) and said catechin extracted from green tea (containing EGCE, EGC, ECG and EG) can induce LoVo cell to die and effect its growth period. Its advantages are high curative effect and no toxic by-effect.

Description

technical field [0001] The invention relates to a curcumin-catechin method for treating malignant tumors. Background technique [0002] There are many methods currently used to treat malignant tumors. Curcumin is a phenolic pigment extracted from the rhizome turmeric of Zingiberaceae. It is mainly used as a natural food coloring and incense in the folk; catechin is the main ingredient in green tea. Components, it is reported that green tea has anti-tumor effect, but the method of using curcumin-catechin to treat malignant tumors is not yet recorded in the world. Contents of the invention [0003] The purpose of the present invention is to provide a curcumin-catechin method for treating malignant tumors by using traditional Chinese medicine and tea to achieve anti-cancer (colorectal cancer) and inhibition and killing of tumor cells (LOVO). [0004] The object of the present invention is achieved like this: a kind of curcumin-catechin method for treating malignant tumor is ...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P35/00
Inventor 张振书张亚历谭晓华陈宏赖卓胜周殿元
Owner NAN FANG HOSPITAL