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Oral liquid compositions

A composition and carbohydrate technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, active ingredients of hydroxyl compounds, etc., can solve the problems that soft gelatin capsules cannot be used

Inactive Publication Date: 2003-04-02
AAIPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This problem prevents the drug formulation in US Patent 5,183,829 from being used in soft gelatin capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Preparation of Liquid Diclofenac Sodium Compositions

[0098]-Add 35.95g of polyethylene glycol 400 (PEG400) into a 100mL glass beaker, stir the PEG400 with a stirring bar on the stirring bed, heat and keep it at about 45-55°C. Slowly add 3.15g of PVP K29-32 to the beaker. After PVP K29-32 was completely dissolved (observed by naked eyes), 3.15 g of sodium clofenac was added, the mixture was cooled to room temperature, and then 1.5 g of polysorbate 80 was added. The mixture was stirred for about two minutes, 5.0 g of glycerin was added and the mixture was stirred for another about two minutes, then 1.25 g of hydrochloric acid was added to give a slightly cloudy solution. The mixture was stirred for about 10-15 minutes more. The composition can be used as an oral solution or used to fill soft gelatin capsules using standard procedures.

Embodiment 2

[0100] With the preparation method of embodiment 1, prepare following composition:

[0101] %w / w

[0102] Sodium Diclofenac 6.3

[0103] Polyethylene glycol 400 71.9

[0104] 2N hydrochloric acid 2.5

[0105] Glycerin 10.0

[0106] Polysorbate 80 3.0

[0107] PVP K29-32 6.3

[0108] 100.0%

Embodiment 3

[0110] Preparation of liquid cromolyn sodium compositions

[0111] Add 37.0g of polyethylene glycol 400 (PEG400) into a 100mL glass beaker, stir the PEG400 with a stirring bar on the stirring bed, heat and keep it at about 45-55°C. Add 5.0 g of glycerin to the beaker, continue stirring for about 2 minutes, then add 2.5 g of pure water, and stir the mixture for about 2-3 minutes. 2.0 g of PVP K29-32 was then added to the mixture with stirring until the PVP K29-32 was completely dissolved (by visual inspection). Then 2.0 g of sodium cromolyn was added and the mixture was stirred until the sodium cromolyn was completely dissolved (by visual inspection). The mixture was cooled to room temperature, then 1.5 g polysorbate 80 was added. The mixture was stirred for about 10-15 minutes, resulting in a slightly hazy solution. The composition can be used as an oral solution or used to fill soft gelatin capsules using standard procedures.

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PUM

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Abstract

The present invention relates to novel, liquid and semi-solid pharmaceutical compositions which can be administered in liquid form or can be used for preparing capsules containing such pharmaceutical compositions. Also provided are methods of using and processes for preparing the pharmaceutical compositions of the present invention.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of Serial No. 09 / 232,354, filed January 15, 1999, the disclosure of which is hereby incorporated by reference in its entirety, and claims Serial No. 60 / 071,865, filed January 20, 1998 The disclosure of which is hereby incorporated by reference in its entirety. field of invention [0003] The present invention relates to pharmaceutical compositions of high quality for oral use, and methods of using such compositions for enhancing the rate and rate of absorption of pharmaceutically active ingredients in such compositions, and for reducing the rate of absorption of pharmaceutically active ingredients in such compositions Gastric irritation induced or caused by ingredients. The pharmaceutically active ingredient of the composition of the present invention comprises at least one pharmaceutically active agent comprising at least one acid moiety, preferably a carboxylic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/07A61K9/00A61K9/08A61K9/48A61K9/62A61K9/66A61K31/00A61K31/19A61K31/191A61K31/192A61K31/195A61K31/196A61K31/198A61K31/203A61K31/215A61K31/352A61K31/366A61K31/40A61K31/403A61K31/404A61K31/405A61K31/407A61K31/43A61K31/4439A61K31/445A61K31/5386A61K45/00A61K47/10A61K47/26A61K47/30A61K47/32A61K47/34A61K47/38A61P1/04A61P25/04A61P29/00
CPCA61K31/19A61K9/4866A61K31/192A61K31/4439A61K9/4858A61K31/405A61K31/445A61K31/352A61K31/196A61K9/485A61K9/0095A61P1/04A61P25/04A61P29/00A61K31/00
Inventor 爱德华·S·威尔逊劳拉A·特雷斯皮蒂克里斯蒂M·克拉克阿索克J·德塞格伦A·梅耶弗里德里克D·桑西里奥
Owner AAIPHARMA