Method of anticipating interaction between proteins

A prediction method and protein technology, applied in the field of prediction of protein-protein interactions, can solve problems such as lack of information on protein-protein interactions
CN1416549AInactive Publication Date: 2003-05-07DAIICHI SEIYAKU CO LTD +1
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Applications(China)
Current Assignee / Owner
DAIICHI SEIYAKU CO LTD
Publication Date
2003-05-07
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The present invention relates a method for predicting a protein or polypeptide (B) that interacts with a specific protein or polypeptide (A), wherein the method is characterized by comprising: 1) decomposing the amino acid sequence of protein or polypeptide (A) into a series of oligopeptides having a pre-determined length as sequence information; 2) searching, within a database of protein or polypeptide amino acid sequences, for a protein or polypeptide (C) comprising an amino acid sequence for each member of the series or for a protein or polypeptide (D) comprising an amino acid sequence homologous to an amino acid sequence for each member of the series; 3) carrying out local amino acid sequence alignment between said protein or polypeptide (A) and the detected protein or polypeptide (C) or detected protein or polypeptide (D); and 4) predicting whether the detected protein or polypeptide (C) and / or protein or polypeptide (D) is a protein or polypeptide (B) that interacts with the protein or polypeptide (A) based on the results of the local amino acid sequence alignment and a value calculated from a frequency of amino acids and / or a frequency of said oligopeptides in said amino acid sequence database; and to a recording medium for carrying out the above method, a device comprising the recording medium, and proteins obtained thereby.
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Description

technical field

[0001] The present invention relates to the prediction of the interaction between proteins, the prediction method and device, and the protein obtained by the method and the device. technical background

[0002] Many proteins perform their functions while interacting with other proteins or with the same protein. Elucidating the interaction between proteins is very important in the development of pharmaceuticals and the improvement of varieties in agriculture. In particular, with the progress of analysis of genomes and cDNAs of various organisms including pathogenic microorganisms, the number of newly discovered genes with unknown functions and their encoded proteins has increased rapidly. If the interaction between proteins can be clarified, it may be possible to predict the function of those proteins whose function is unknown.

[0003] For the purpose of elucidating the interaction between proteins, for a certain protein, the method adopted in order to find...

Claims

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