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Compound prunella spike capsule and preparation process thereof

A technology of Prunella vulgaris and compound recipe, which is applied to compound Prunella vulgaris capsules for treating essential hypertension and the field of preparation thereof, can solve the problems of small toxic and side effects, small dosage, etc., achieves drug quality assurance, high extraction efficiency, and reduces labor the effect of strength

Inactive Publication Date: 2003-08-06
WUHAN UNIV OF TECH
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AI Technical Summary

Problems solved by technology

[0004] Supercritical carbon dioxide extraction technology is one of the means for the modernization of traditional Chinese medicine technology. It has laid a scientific foundation for the quality control and stability of traditional Chinese medicine preparations. The use of supercritical carbon dioxide extraction technology for research on modern Chinese medicine compound preparations for the treatment of hypertension is in line with the modernization of traditional Chinese medicine. The development trend of the development trend, there are very few traditional Chinese medicines for lowering blood pressure in the market, and supercritical CO 2 Extraction and development of traditional Chinese medicine for lowering blood pressure has not yet been done, so as long as a kind of traditional Chinese medicine for lowering blood pressure can be developed with existing modern technology and production, and has good curative effect, small dosage, and less toxic and side effects, it must be welcomed by the majority of hypertensive patients

Method used

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Embodiment Construction

[0024] In the preparation example of the compound Prunella vulgaris Capsules, Prunella vulgaris, Yangjinhua, Apocynum, banana peel, Uncaria, hawthorn, cassia, and chrysanthemum are identified and classified, processed according to the method stipulated in the Chinese Pharmacopoeia; and then pulverized through a 40-mesh sieve, Weigh each medicinal material according to the prescription in Table 1, and mix them evenly; weigh 260g of the mixed coarse powder, place it in a FY121-50-01 type supercritical extraction device, control the extraction pressure to 35MPa, and the temperature to 50°C. 2 Carry out extraction for 1 hour, then control pressure 8.8MPa, temperature 40 ℃, emit the separated extraction extract 1 and control pressure 5.8MPa, temperature 35 ℃, emit the separated extraction extract 2; Then add 300ml95% (volume) ethanol solution Extraction, control extraction pressure 35MPa, temperature 50 ℃, use CO 2 Carry out extraction for 1 hour, then control the pressure at 8.8 M...

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Abstract

The preparation method of compound prunella spike capsule for curing hypertension with obvious therapeutic effect free from toxic reaction includes the following steps: using prunella spike, datura flower, dogbane and banana peel or also containing uncaria stem and thorn, crataegus fruit, fetid cassia seed and chrysanthemum flower as raw material, adopting supercritical CO2 extraction technique to extract paste, spray-drying to obtain fine granules, and capsulizing so as to obtain the invention product. Said capsule, and capsulizing so as to obtain the invented product. Said capsule contains effective component oleanolic acid whose content is greater than or equal to 0.2 mg / one capsule (0.33g), also contains hyperoside and quercetin.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating essential hypertension and a preparation method thereof, in particular to a compound Prunella vulgaris capsule for treating essential hypertension and a preparation method thereof. Background technique [0002] Hypertension is one of the diseases with the highest morbidity in our country, especially the elderly suffer from it more often. Now the market mainly relies on western medicine and imported medicine to treat it. Not only the price is high, but also it is easy to produce drug resistance and side effects Big, in order to solve the medical desire of the majority of patients for traditional Chinese medicine antihypertensive drugs, inherit and carry forward the theory of traditional Chinese medicine in my country, and develop a modern medicine for treating hypertension with low price, small dosage, good curative effect and small side effects from traditional Chin...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/56A61P9/12
Inventor 楼一层
Owner WUHAN UNIV OF TECH
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