Controllable release system of glucocorticoid and its preparation and use

Abstract

The invention discloses a controllable release system of glucocorticoid, the preparing method and the application. The controllable release sytem is the glucocorticoid microcapsule, uses natural biodegradable high-molecular material as the base material of glucocorticoid drug, and adopts ultrasonic micro-capsulizating technique of combination of emulsification and mechanical mixing to wrap the drug in the microsphere composed of the base material to make microcapsule; further prepare the drug's powder, capsule, plaster, tablet and injection or pill, able to effectively control the release rate and stability of the drug, maintain the needed blood concentration, and on the premise of assuring the cure effect, largely reduce the frequency of dosing or injecting and the side effect of the drug.

Description

technical field

[0001] The invention belongs to the field of medicines, and more specifically relates to a controllable release system of glucocorticoids and its preparation and application. Background technique

[0002] Glucocorticoids are a class of steroid hormones secreted by the adrenal cortex, which have strong pharmacological effects such as anti-inflammatory, anti-allergic, immunosuppressive and anti-toxic. Clinically, it is widely used in the treatment of arthritis, ophthalmic inflammation, anti-rejection after keratoplasty, rheumatoid arthritis, systemic lupus erythematosus, vasculitis and other autoimmune diseases.

[0003] Traditional drug preparations use general drug carriers. At the initial stage after taking the drug or injection, the blood drug concentration will gradually increase according to the body's absorption of the drug, and the highest concentration may exceed the poisoning limit concentration; then with the release of the drug in the drug , the am...