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Use of [š�-hydroxy-N-methyl-L-leucine9] cyclosporin A for hair growth

A kind of technology of hair growth and cyclosporine, applied in the field of hair growth promoters

Inactive Publication Date: 2004-04-21
LG HOUSEHOLD & HEALTH CARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, all the cyclosporins used in the above-mentioned documents have strong immunosuppressive activity, so their use in general hair loss treatment is limited, although they have excellent hair regeneration effect

Method used

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  • Use of [š�-hydroxy-N-methyl-L-leucine9] cyclosporin A for hair growth
  • Use of [š�-hydroxy-N-methyl-L-leucine9] cyclosporin A for hair growth
  • Use of [š�-hydroxy-N-methyl-L-leucine9] cyclosporin A for hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] [γ-Hydroxy-N-methyl-L-leucine 9 ] Preparation of cyclosporin A

[0095] In this example, [γ-hydroxy-N-methyl-L-leucine with hair regeneration effect after microbial transformation is described 9 ] Preparation of cyclosporine A.

[0096] Pseudonocardia autotrophica KCTC 9441 was used as a strain for producing cyclosporin A metabolites. The strain was cultured in a medium containing 0.7% glucose, 0.45% yeast extract, 0.5% malt extract, 1.0% soluble starch and 0.005% CaCO 3 culture medium at 27°C.

[0097] The strain was grown in a fermenter, with a 4-day pre-culture in Erlenmeyer flasks before the official culture started. The main culture was carried out in a 4L fermenter using the medium described above. 24 hours after the start of the main culture, cyclosporin A dissolved in methanol was added to a concentration of 100 mg / l, followed by further culture for 72 hours. At that point, the medium was extracted with an amount of ethyl acetate equivalent to the total me...

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Abstract

The present invention discloses a hair growth promoter comprising [ gamma -hydroxy-N-methyl-L-leucine9 ] cyclosporin A, in which a hydroxy group is added to a gamma carbon of N-methyl-L-leucine at No. 9 position in cyclosporin A by metabolic action of a microorganism, as an active ingredient.

Description

technical field [0001] The present invention relates to a hair growth promoter comprising a derivative of cyclosporin as an active ingredient. More specifically, the present invention relates to a hair growth promoter comprising [γ-hydroxy-N-methyl-L-leucine 9 ]Cyclosporine A ([Y-hydroxy-N-methyl-L-leucine 9 ]Derivatives of cyclosporin A) as active ingredients. Background technique [0002] The average human scalp has about 100,000 to 150,000 hairs, and the growth of each hair can be divided into three stages: anagen (anagen), middle anagen (catagen) and telogen (telogen). fall off. This cycle of hair growth is repetitive, and each cycle differs in duration from the others, ranging from 3 to 6 years. Therefore, under normal circumstances, an average adult loses about 50 to 100 hairs per day. In general, alopecia refers to a phenomenon in which the time of anagen is shortened and the percentage of hairs in catagen and telogen increases, thereby causing excessive and abno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/00A61K8/64A61K8/99A61K38/00A61K38/13A61P17/14A61Q5/00A61Q5/02A61Q5/12A61Q7/00
CPCA61K8/64A61Q5/02A61K38/13A61Q7/00A61Q5/12A61P17/14
Inventor 金祥年安浩井李昌雨金正勋金钟一李宪植李珉镐赵浩成金胜镇朴弘淳
Owner LG HOUSEHOLD & HEALTH CARE LTD
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