Highly concentration water-soluble vitamin for intravenous injection and preparation and use

A technology of water-soluble vitamins and vitamins, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of lack of supplementary needs and inability to meet water-soluble vitamins, so as to reduce side effects, improve treatment or Auxiliary treatment effect, quick effect of vitamin supplementation

Inactive Publication Date: 2004-11-10
吴良信 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under special pathological conditions, such as persistent high fever, burns, liver damage, major surgery, etc., the demand for water-soluble vitamins increases, and current clinical administration cannot meet the supplementary needs of clinical severe water-soluble vitamin deficiency

Method used

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  • Highly concentration water-soluble vitamin for intravenous injection and preparation and use
  • Highly concentration water-soluble vitamin for intravenous injection and preparation and use
  • Highly concentration water-soluble vitamin for intravenous injection and preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: 1.86g thiamine nitrate, 2.94g riboflavin sodium phosphate, 24.0g nicotinamide, 2.94g pyridoxine hydrochloride, 9.9g sodium pantothenate, 60.0g vitamin C, 36mg biotin, 0.24g folic acid, 3.0 mg Vitamin B 12 , 0.15g methyl p-hydroxybenzoate, 0.15g disodium edetate, and 90g glycine were dissolved in water for injection, adjusted to 900ml with water for injection, filtered through a 0.22μg microporous membrane, subpackaged into 3ml bottles, and Freeze-dry in a freeze dryer, and press the cap to obtain the required high-concentration water-soluble vitamin freeze-dried powder injection for intravenous injection.

Embodiment 2

[0016] Example 2: 1.86g thiamine nitrate, 2.94g riboflavin sodium phosphate, 24.0g nicotinamide, 2.94g pyridoxine hydrochloride, 9.9g sodium pantothenate, 60.0g vitamin C, 36mg biotin, 0.24g folic acid, 3.0 mg Vitamin B 12 , Dissolve 90mg of disodium edetate in 300ml of water for injection, filter through a 0.22μg microporous membrane, pack into 300 bottles, freeze-dry in a lyophilizer, and press the cap to obtain the required high-concentration water-soluble solution for intravenous injection. Sexual vitamin freeze-dried powder injection.

Embodiment 3

[0017] Example 3: 1.42g thiamine nitrate, 3.60g riboflavin sodium phosphate, 27.3g nicotinamide, 2.28g pyridoxine hydrochloride, 7.63g sodium pantothenate, 53.0g vitamin C, 42mg biotin, 0.20g folic acid, 2.4 mg Vitamin B 12 , Dissolve 90mg of disodium edetate in 300ml of water for injection, filter through a 0.22μg microporous membrane, pack into 300 bottles, freeze-dry in a lyophilizer, and press the cap to obtain the required high-concentration water-soluble solution for intravenous injection. Sexual vitamin freeze-dried powder injection.

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PUM

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Abstract

The present invention relates to a high-concentration-type water soluble vitamin used for intravenous injections, with each bottle containing 6.2 +-1.6 mg aneurine mononitrate, 9.8+-2.5 mg lactoflavin sodium phosphate, 80+-20 mg nicotinic amide, 9.8+-2.5 mg phosphopyridoxamine, 33.0+-8.3 mg panthoject, 200+-50 mg vitamin, 120 +-30 mu g biotin, 0.8+-0.2 mg acidum folicum, 10.0+-2.5 mu g vitamin B12 and 1-6ml water for injection. The preparing method is as follows: stirring the components mentioned above with water for injection until they are entirety dissolved, freezing-drying them in a freezing-drying machine, pressing them to prepare the water soluble vitamins used for intravenous injection. The water soluble vitamins used for intravenous injection in accordance with the present invention can be used for guarding against and curing cacotrophia caused by deficiency of water soluble vitamins and for auxiliary cure of chronic diseases such as chronic hepatic disease and the like; the water soluble vitamins used for intravenous injection possesses advantages of rapid vitamin supplying, medicament curative effect enhancement, reduced side-effects and the like, can satisfy clinical require for supplying of serious water soluble vitamins deficiency caused by diseases.

Description

technical field [0001] The invention relates to a high-concentration water-soluble vitamin for intravenous injection and its preparation method and application. Background technique [0002] Water-soluble vitamins are necessary to maintain the normal function of the body, and water-soluble vitamins should be taken in a certain amount every day to meet the needs. At present, oral administration, individual administration of various water-soluble vitamins, or injection of vitamin supplements are mostly used in clinical practice. Because water-soluble vitamins are stored in the body very little, once they are exceeded, they will be excreted quickly. The dosage is based on the daily vitamin requirements. The amount was slightly increased, and no higher doses were used. Under special pathological conditions, such as persistent high fever, burns, liver damage, major surgery, etc., the demand for water-soluble vitamins increases, and current clinical administration cannot meet the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/714A61P3/02
Inventor 吴良信丁虹童静吴建元陈俊
Owner 吴良信
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