Chinese traditional medicine buccal tablets for preventing and treating caries and its preparation

A buccal tablet and traditional Chinese medicine technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problem of rare drugs or health care products for preventing dental caries, peeling of oral mucosa, oral and intestinal bacteria group disproportion

Active Publication Date: 2004-11-17
JIANMIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the fluorine-containing, chemical or mixed preparations of Chinese and Western medicines on the market today, among which antibiotics, such as penicillin, erythromycin, tetracycline and spiramycin, can effectively prevent the occurrence and development of dental caries, but will cause oral and intestinal flora Proportional imbalance occurs, which leads to other diseases; although chlorhexidine can agglutinate cells by inhibiting Streptococcus mutans adhering to the surface of teeth, and achieve the purpose of sterilization and control of plaque formation, long-term use can cause various diseases such as Side effects such as peeling and ulceration of oral mucosa, discoloration of tongue, teeth and dental silicate fillings
Some people have also done research on the prevention of dental caries with vaccines, preservatives, and glucan transferases, but they have not been applied clinically so far.
[0003] At present, there are not many caries prevention drugs or health care products prepared by pure natural drugs at home and abroad, and most of the existing products are western or traditional Chinese medicines containing fluoride or chlorhexidine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 80kg of Ligustrum lucidum, add 95% ethanol, heat and reflux in a closed device to extract three times, each time for 2 hours, combine the filtrate, reclaim ethanol, concentrate into a thick paste, and set aside; take 5kg of honeysuckle and 30kg of licorice and decoct twice with water, Combine the decoctions for 3 hours each time, filter, concentrate the filtrate into a thick paste, and set aside; add the above two thick pastes to an appropriate amount of mannitol powder, mix well, granulate, and add 1% orange juice to the granules after drying powder, 0.2% menthol, 0.5% magnesium stearate, after mixing, tablet, make every 0.4g, promptly get the medicine buccal tablet of the present invention.

[0027] The traditional Chinese medicine buccal tablet of the present invention has the functions of nourishing yin, clearing away heat, detoxifying and killing insects, and can be used for the prevention and treatment of dental caries. Since the extracted components have not ...

example 2

[0029] Take 60 kg of Ligustrum lucidum, decoct once with water, filter, and extract the filtrate with ethanol reflux for 3 times, combine the extracts, filter, recover ethanol, concentrate into extract, and wash the extract with 80°C water for 4 times. After filtering, the filter residue was reflux extracted twice with 1% activated carbon and ethanol, filtered, recovered ethanol, and concentrated into a thick paste. Take 2Kg of honeysuckle, add water to decoct twice, combine the decoction, filter, and concentrate the filtrate into a thick paste. Take 60Kg of licorice, crush it into a coarse powder, add water to decoct twice, combine the decoction, filter, and let the filtrate stand for 24 hours, take the supernatant, concentrate it into a thick paste, add an acidic solution to adjust the pH value to 3, let it stand, Filter, wash the precipitate with water until the pH is 4, filter, dry the precipitate, add an organic solvent for reflux extraction twice, combine the extracts, f...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine buccal tablet for preventing and treating dental caries, and its preparing process, wherein the tablet is prepared from ligustrum japonicum, honeysuckle flower, and licorice root through the steps of medicinal material extracting, concentration or drying, granulation, and pelleting formation.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine, in particular to a traditional Chinese medicine buccal tablet which has the functions of nourishing yin and clearing the lung, detoxifying and killing insects, and can be used for the prevention and treatment of dental caries. The present invention further provides its preparation method. Background technique [0002] Dental caries is a common oral disease, and the World Health Organization lists it as the third disease after cardiovascular and cancer. The incidence of dental caries in my country accounts for about 50% of the total population, and the incidence rate of children is as high as 80%, and it is on the rise year by year. It can affect the development of permanent teeth, making them misaligned, and can affect facial appearance, chewing and development. Therefore, the research and production of medicines and health care products for the prevention and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/02
Inventor 熊富良黄志军张惠明徐绍新曹智华王玉巧王永平梁前荣
Owner JIANMIN PHARMA GRP CO LTD
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