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Preparation of sodium probenecid and potassium probenecid, compound injection prepared by sodium probenecid, potassium probenecid and beta-lactam antibiotics, and use thereof

A technology of probenecid sodium and probenecid potassium, which is applied in the field of powder injection and freeze-dried powder injection, can solve the problem of probenecid sodium that has not yet been seen, and achieve the effect of eliminating hemolysis and prolonging the half-life

Active Publication Date: 2005-06-29
BEIJING KANGZHENG KANGREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This invention relates to combinations between certain drugs that work together for longer periods of time or even outperforming each other's functions over their entire life span without causing harmful side reactions like those caused by older medications such as amoxycetone.

Problems solved by technology

This patented technical problem addressed in this patents relates to finding new drugs called probibenecid instead of existing ones like other types of beta lactic acid antimicrobics because they are more effective at killing Gram negative microorganisms than older agents such as penicilast.

Method used

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  • Preparation of sodium probenecid and potassium probenecid, compound injection prepared by sodium probenecid, potassium probenecid and beta-lactam antibiotics, and use thereof
  • Preparation of sodium probenecid and potassium probenecid, compound injection prepared by sodium probenecid, potassium probenecid and beta-lactam antibiotics, and use thereof
  • Preparation of sodium probenecid and potassium probenecid, compound injection prepared by sodium probenecid, potassium probenecid and beta-lactam antibiotics, and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0347] Example 1: Dissolve 22 kilograms of sodium hydroxide in 200 liters of purified water, add 142 kilograms of probenecid after all the dissolution, heat to 60° C., adjust the pH to above 7.5, and keep stirring until the pH value is basically constant. Under the condition of 60°C, it is sterilized by filtration through a 0.45 μm filter membrane, and then finely filtered through a 0.22 μm filter membrane to remove pyrogens, and dried under sterile conditions to obtain the raw material of probenecid sodium that meets the standards for human drug injections. White or off-white crystalline powder.

[0348] Probenecid sodium and penicillin G sodium are mixed under aseptic conditions at a weight ratio of 1:3, subpackaged under aseptic conditions, and finally made into a powder injection.

Embodiment 2

[0349] Example 2: Dissolve 28 kg of sodium hydroxide in 280 liters of purified water, add 143 kg of probenecid after all the dissolution, heat to 65°C, adjust the pH to above 8, and keep stirring until the pH value is basically constant. Under the condition of 65°C, it is sterilized by filtration through a 0.45 μm filter membrane, and then finely filtered through a 0.22 μm filter membrane to remove pyrogens, and dried under sterile conditions to obtain the raw material of probenecid sodium that meets the standards for human drug injections. White or off-white crystalline powder.

[0350] Probenecid sodium and ampicillin sodium are mixed under aseptic conditions at a weight ratio of 1:2.8, subpackaged under aseptic conditions, and finally made into a powder injection.

Embodiment 3

[0351] Example 3: Dissolve 40 kg of sodium hydroxide in 300 liters of purified water, add 150 kg of probenecid after all dissolved, heat to 70°C, adjust pH to 10, and keep stirring until the pH value is basically constant. Under the condition of 70°C, it is sterilized by filtration through a 0.45 μm filter membrane, then finely filtered through a 0.22 μm filter membrane to remove pyrogens, and dried under sterile conditions to obtain the raw material of probenecid sodium that meets the standards for human drug injections. White or off-white crystalline powder.

[0352] Probenecid sodium and cefazolin sodium are mixed under aseptic conditions at a weight ratio of 1:2, subpackaged under aseptic conditions, and finally made into a powder injection.

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Abstract

The invention relates to a preparation of and compound injection formed by ª‰-lactam antibiotics and it and its application, which belongs to chemical chemical tragacanth . Make intosodium salt and kali salt, combined with ª‰-lactam antibiotics thy are then changes into powder injection; which can intravenous injection or intravenous drip with ª‰-lactam antibiotics at the sametime. It can remarktably increase the square below the curve, prolong half life of blood elimination (t1/2ª‰) of antibiotics, and the period of medicine density of ª‰-lactam antibiotics in blood surpassing that of the corresponding germ MIC; it can also reduce abuse of antibiotics, avoid generation and development of bacterial strain tolerant to medicine, has good safety and curative effect, stable quality and convenient use.

Description

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Claims

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Application Information

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Owner BEIJING KANGZHENG KANGREN BIOTECH
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