Use of kaempferol and its derivative in preparing medicines for depression or dementia

A technology of kaempferol and its derivatives, which is applied in the field of medicine and can solve problems such as kaempferol and Alzheimer's disease that have not yet been seen

Inactive Publication Date: 2005-10-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no use of kaempferol and its derivatives for the prevention and treatment of depression or senile dementia

Method used

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  • Use of kaempferol and its derivative in preparing medicines for depression or dementia
  • Use of kaempferol and its derivative in preparing medicines for depression or dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The antidepressant and antidementia efficacy experiments of kaempferol and its derivatives are described in detail.

[0016] For the preparation method of kaempferol and its derivatives used in this experiment, refer to the patent (application number: 02137548.8) applied by the inventor for details.

[0017] Pharmacology and efficacy experiments:

[0018] 1. Antidepressant pharmacodynamic experiments of kaempferol and its derivatives:

[0019] The mouse forced swimming test is a classic animal model of depression, so it is used to verify the prevention and treatment effect of kaempferol and its derivatives on experimental animal depression.

[0020] 1. Experimental animals

[0021] Kunming mice, male, 20-24 g, grouped with 10 mice per cage, free to forage and drink, room temperature 23±2°C, natural light.

[0022] 2. Experimental method

[0023] According to the method on page 104 of "Modern Pharmacological Experimental Methods" (Volume 1) edited by Zhang Juntian. ...

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PUM

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Abstract

An application of kaempferol and its derivatives in preparing the medicines for preventing and treating depression and dementia is disclosed.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to a new application of kaempferol and derivatives thereof in preparing medicines for preventing and treating depression or dementia. Background technique [0002] Depression and Alzheimer's disease are two common and frequently-occurring diseases. Among them, depression is a common mental illness characterized by significant and persistent depression, stiff behavior and pessimistic world-weariness, with a high incidence and a serious threat to the lives of patients; It is characterized by progressive and irreversible cognitive and memory decline in the central nervous system, accompanied by profound cognitive impairment and abnormal behavior. With the aging of the population, its incidence is increasing year by year. It threatens the life and health of the elderly and affects the quality of life of the elderly. Therefore, finding effective medicines for preventing and treating de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/24A61P25/28
Inventor 郭美丽张戈薛芊姜远英
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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