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Rabdosia rubescens drops and preparation thereof

A technology of Radix Oryzae and Grass Dropping Pills, which is applied in pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients. Avoid gastrointestinal irritation symptoms, improve bioavailability, accelerate dissolution and absorption

Inactive Publication Date: 2005-10-12
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
Syrup drugs also have the disadvantages of low drug content, difficulty in taking and measuring accurately, and inconvenient taking and carrying.
[0012] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] Several sets of specific examples are now used to further illustrate the preparation method of Donglingcao dripping pills of the present invention.

[0036] The first group: single matrix test

[0037] 1. Take some rubescens, chop it, add 10 times the amount of ethanol, heat and press (0.15mPa), extract for 16h, collect the extract, recover the ethanol, add 3 times the amount of medicine residue with water, decoct for 2h, filter, and combine The alcohol and water extracts are concentrated to an appropriate amount, then dried at low temperature and reduced pressure, and pulverized to obtain a dry powder.

[0038] 2. Matrix: polyethylene glycol (1000~20000) , Polyoxy 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. Medicinal carrier

[0039] 3. Proportioning—in g or kg, in parts by weight, drug extract: matrix=1:1~1:9;

[0040] 4. Then prepare according to the process ...

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PUM

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Abstract

A dripping pill of rabdosia for treating chronic tonsillitis, pharyngitis, laryngitis and stomatitis is disclosed, which is based on the rabdosia syrup. Its advantages are high release speed and quickly taking its high curative effect.

Description

Technical field [0001] The invention relates to a medicinal composition that has the effects of clearing away heat and detoxifying and is used for the treatment of chronic tonsillitis, pharyngitis, laryngitis, stomatitis and other diseases, and in particular relates to a medicinal composition made from a traditional Chinese medicine prescription rubescens syrup based on a modified dosage form The pharmaceutical composition is an oral drop pill preparation. Background technique [0002] According to national drug standard WS 3 -Rubescens syrup prepared by the formula and extraction process given in B-1915-95 is a kind of heat-clearing and detoxifying; it is used for the treatment of chronic tonsillitis, pharyngitis, laryngitis, stomatitis and other symptoms. After years of clinical verification, the quality is stable and the curative effect is definite. It is a common pharmaceutical preparation used clinically and at home to treat the above diseases. [0003] The following is the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/02A61P11/04
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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