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Isatis root drops and preparation thereof

A technology of Banlangen and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve problems such as long dissolution time, complex components of traditional Chinese medicine injections, and dust in granules, so as to avoid gastrointestinal Tract irritation symptoms, enhanced bioavailability, accelerated dissolution and absorption

Active Publication Date: 2005-10-12
葵花药业集团(佳木斯)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
The syrup preparation contains higher sugar content, which is not conducive to diabetics to take
Tea preparations are complicated to take; granules contain dust; adverse reactions of traditional Chinese medicine injections have serious consequences, and anaphylactic shock caused by traditional Chinese medicine and its preparations ranks first, and there is an increasing trend year by year, which is related to more clinical applications
The composition of traditional Chinese medicine injections is relatively complex. Injecting this mixture into the human body from the blood vessels and forcing the human body to metabolize it is already potentially dangerous. If it is combined with other drugs, the possible reactions are often difficult to predict
[0017] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0044] Several sets of specific examples are now used to further illustrate the preparation method of the Banlangen dripping pill of the present invention.

[0045] Group 1: Tests on a single substrate

[0046] 1. Preparation of Radix Isatidis extract: Take a few of Radix isatidis, add water to decoct twice, the first time is 2h, the second time is 1h, filter, combine the filtrate, let stand, take the supernatant night liquid and shrink to an appropriate amount, then get the extract soaked Paste; or after drying at low temperature, reduced pressure, and crushing to obtain dry powder;

[0047] 2. Matrix: polyethylene glycol (1000~20000) , Polyoxy 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. Medicinal carrier

[0048] 3. Mixing ratio: in g or kg, in parts by weight, drug extract: matrix=1:1~1:9;

[0049] 4. Then prepare according to the process of [Preparation Method] 4-7...

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PUM

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Abstract

A dripping pill of isatis root for treating tonsillitis, parotitis, sore throat, infectious hepatitis and infantile measles is disclosed, which is based on isatis root syrup. Its advantages are high release speed and quickly taking its high curative effect.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition for treating tonsillitis, mumps, sore throat, prevention and treatment of infectious hepatitis, measles in children, etc., which has the effects of clearing heat and detoxification, cooling blood to relieve throat, and reducing swelling, and particularly relates to traditional Chinese medicine. A medicinal composition oral dripping pill preparation based on the prescription Radix isatidis syrup or Radix isatidis tea preparation through the modification of the dosage form. Background technique [0002] According to the national drug standard WS 3 -The Radix Isatidis syrup prepared by the formula and extraction process given in B-0952-91 is a kind of heat-clearing and detoxifying, cooling blood and pharyngeal, reducing swelling, used for tonsillitis, mumps, sore throat, Syrup preparations for the treatment of infectious hepatitis, measles and other diseases in children have been clinically verified...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/16A61P11/04A61P31/14
Inventor 曲韵智
Owner 葵花药业集团(佳木斯)有限公司
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