Polypeptides and nucleic acids encoding these and their use for the prevention, diagnosis or treatment of liver disorders and epithelial cancer

Abstract

The invention relates to polypeptides and nucleic acids encoding these and to their use for the diagnosis, prevention and / or treatment of liver disorders and neoplastic disorders, especially cancer of the liver and other epithelial tissues, benign liver neoplasms such as adenoma and other proliferative liver disorders such as focal nodular hyperplasia (FNH) and cirrhosis. The invention further relates to methods of diagnosing and treating these disorders.

Description

Technical field [0001] The present invention relates to polypeptides and nucleic acids encoding these polypeptides and their use in the prevention, diagnosis and / or treatment of liver disorders and tumorigenic disorders, especially cancers of the liver and other epithelial tissues, benign liver tumors such as adenomas and other hyperplastic livers Use of disorders such as focal nodular hyperplasia (FNH) and cirrhosis. The invention also relates to methods of diagnosing and treating these disorders. Background technique [0002] The general feature of cancer development is genetic mutations that alter important cellular pathways including, for example, proliferation, apoptosis (cell death), response to stress, and the activity of epithelial / stromal interactions. It is increasingly recognized that the identification of nucleic acids that are deregulated in cancer can provide important new insights into the mechanism of tumor transformation. The identification of deregulatory nuclei...

AI Technical Summary

Problems solved by technology

Surgical intervention remains the best treatment option but it is not possible to precisely define the extent of the tumor

Therefore, this invasive approach is not optimal from a therapeutic point of view

Furthermore, lack of early diagnostics for specific liver dysfunction most often leads to further progression of the disease, which further confounds treatment options and significantly increases patient mortality from these diseases (Jansen P.L., 1999, Neth.J.Med.55:287 -292)

Thus, until now no satisfactory therapy has been developed to be able to intervene in disorders of the liver, and other epithelial cancers

Furthermore, in the state of the art, the identification of different subtypes of liver disorders revealed by differential gene expression such as HCC precursor lesions, benign liver tumors, and metabolic liver diseases such as alcoholic liver disease and cirrhosis has not been published

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