Polypetide from haliotidae (PFH), its preparation and use in bio-medicine

A technology of copeptin and marine organisms, applied in the field of biomedicine, can solve problems such as the effective application of marine organisms, and achieve the effects of improving learning and memory, slowing down neurasthenia, and slowing down insomnia

Inactive Publication Date: 2005-11-02
万平 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of vascular dementia, which ranks first in the incidence of senile dementia in my country, no effective application of any relevant marine organisms has been found in the search; for Baopeptide (Polypetide From Haliotidae, PFH) and its preparation method and appli

Method used

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Examples

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Embodiment Construction

[0017] Below in conjunction with example the present invention will be further described. Take the live abalone, put it into the clean water holding tank, let it discharge body excrement, and then move it to the running pool, peel off the abalone shell, take out the whole abalone viscera, discard its water, and put it into a vertical grinder for crushing Finally, put it into a tissue homogenizer and grind it into a homogenate, place the viscera mass homogenate in a container, add appropriate amount of medical ethanol, 20% sodium benzoate, and 10% aluminum potassium sulfate one by one, the preparation ratio is: abalone viscera mass homogenate Slurry: ethanol: 20% sodium benzoate: 10% aluminum potassium sulfate = 45: 35: 0.8: 1.2, after mixing and stirring, add an appropriate amount of hydrochloric acid to make the pH value 4, centrifuge at 4000r / min for 15min, remove the supernatant, and precipitate Add an appropriate amount of medical ethanol and stir, after cleaning and disin...

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PUM

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Abstract

The invention belongs to the field of biological medicine. **(PFH) is a single-chain polypeptide extracted from internal organs of abalone, with molecular weight less than 105. The composition of primary structure is alanine, arginine, glutamic acid, tryptophan, acimetion, lycine, isoleucine, threonine, leucine, serine, phenylalanine, glycocoll, histidine, praline, valine, cysteine, aspartate. The method for making it is: washing away shells of live abalone, disintegrating and homogenating internal organs, adding proper ethanol, sodium benzoate, aluminum potassium sulfate successively, then adding proper alcaine, centrifuging it to remove supernate, adding proper ethanol to sediment, vacuum drying it to get the product. It is provided with the function of improving blood circulation of the brain and skin, strengthening learning memory capability, improving the sleeping quality. It is adapted to drugs and health food, makeup for preventing and curing senile dementia, hypomnesia, long-run insomnia, nervous prostration, nutritional anemia, xeroderma.

Description

1. Technical field [0001] The invention provides a polypetide from haliotidae (PFH), a preparation method thereof and an application in biomedicine, which belong to the field of biomedicine. 2. Background technology [0002] 1. About senile dementia [0003] Alzheimer's disease is a manifestation of brain circulation disorder and brain dysfunction in the elderly, and is a disease characterized by mental decline and abnormal changes in behavior and personality. Clinical manifestations mainly include memory, abstract thinking and disorientation. At present, the disease is mainly divided into three types: Alzheimer disease AD, vascular dementia VD and mixed dementia. The pathogenesis of Alzheimer's disease is still unclear; vascular dementia is mostly caused by long-term chronic ischemia or acute stroke. The incidence of senile dementia in my country is 2% to 18%, and the incidence of dementia over 65 years old is 3.9%, of which vascular dementia accounts for 68.5%, ranking ...

Claims

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Application Information

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IPC IPC(8): C07K14/08
Inventor 万平万柔赖小俭
Owner 万平
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