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Method for extracting anti-tumour active ingredient from ground beetle

An effective part, anti-tumor technology, applied in the field of extraction, can solve the problems of inability to extract and separate effective components

Inactive Publication Date: 2005-12-21
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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AI Technical Summary

Problems solved by technology

Therefore, it is impossible to extract and separate the effective ingredients that can really fight against tumors, to develop special anti-tumor drugs, and to realize industrialization

Method used

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Embodiment Construction

[0008] Organic solvent extraction - reflux extraction with organic solvents such as absolute ethanol or petroleum ether, and saponification to obtain crude fatty acids; then column chromatography - chromatographic separation. Specific process and steps:

[0009] Take 1000g, heat reflux extraction with an organic solvent such as absolute ethanol or petroleum ether to obtain an extract; recover the solvent to obtain crude fat; you can also take 1000g, and supercritically extract crude fat; add absolute ethanol or methanol, KOH, heat Reflux, evaporate the solvent to dryness to obtain a solid; then dissolve in water, extract with ether, take the water layer, add HCL, adjust the pH value to acidic, extract with ether, and take the ether layer; evaporate the solvent to obtain crude fatty acid; Adsorbent, used to separate fatty acids; use organic solvents such as petroleum ether, chloroform, methanol, ether, ethyl acetate, acetone and acetic acid, and any combination of solvents as e...

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Abstract

The present invention relates to a method for separating and extracting antineoplastic active region fatty acid from Chinese medicinal material wingless cockroach. Said invention adopts organic solvent to extract wingless cockroach to obtain crude fatty acid, then utilizes column chromatography to make separation so as to obtain active region fatty acid, mainly including 7-octadecenic acid, hexadecylic acid, 9-hexadecenoic acid and octadecane acid. Said wingless cockroach extract can be used for curing several malignant tumors.

Description

technical field [0001] The invention relates to an extraction method, in particular to a method for separating and extracting the fatty acid of the effective part of anti-tumor from the traditional Chinese medicine ground beetle. Background technique [0002] At present, the development and application of new anti-tumor chemotherapy drugs are developing rapidly, especially the chemotherapy drugs developed from natural medicines through modification and artificial synthesis, such as paclitaxel, docetaxel, oxalplatin, genza, and isovinca. Drugs such as flower alkali, Capto, Xeloda, and Alimita have certain therapeutic effects. Among them, traditional Chinese medicine is a unique treasure house of natural medicines in my country. [0003] Before the present invention, the medical circle has recognized that the single Chinese medicine Wood Beetle has anti-tumor effect and curative effect, and has inhibitory effect on leukemia cells in vitro, but it is not clear which specific c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 刘宝瑞邹玺钱晓萍
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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