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Antineoplastic nanometer heat sensitive target medicine carrier used combined with chemical therapy and heat therapy

An anti-tumor, heat-sensitive technology, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of changing the activity of chemotherapy drugs, affecting the tumor treatment effect of chemotherapy drugs, and difficulty in synthesis, so as to avoid damage and solve the problem of chemotherapy drugs The effect of activity changes

Inactive Publication Date: 2006-01-18
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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Problems solved by technology

However, the carrier constructed by this method needs to be combined with doxorubicin through chemical bonds. Not only is the synthesis itself difficult, it is difficult to popularize and apply to other chemotherapeutic drugs, but also the activity of chemotherapeutic drugs can be easily changed through chemical bonding, affecting Therapeutic Effect of Chemotherapy Drugs in Controlling Tumor

Method used

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  • Antineoplastic nanometer heat sensitive target medicine carrier used combined with chemical therapy and heat therapy
  • Antineoplastic nanometer heat sensitive target medicine carrier used combined with chemical therapy and heat therapy
  • Antineoplastic nanometer heat sensitive target medicine carrier used combined with chemical therapy and heat therapy

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Embodiment Construction

[0009] The particle size range of the carrier is less than 200 nanometers, which is conducive to long-term circulation in the body without being eliminated.

[0010] The hydrophilic segment has a molecular weight below 15,000, lower than the human kidney domain, and can be excreted through the kidneys.

[0011] The hydrophobic segment is made of polylactic acid, which is a biodegradable material and is non-toxic to the human body after hydrolysis. Other substances having the same or similar properties may also be used.

[0012] The hydrophilic segment is a radical copolymerization reaction:

[0013] Using N-isopropylacrylamide (NIPAAm) and acrylamide (Aam) as monomers to polymerize to form a copolymer poly(NIPAAm-co-Aam), the reaction equation is

[0014]

[0015] Chemotherapy drugs are encapsulated by hydrophobic fragments as carriers.

[0016] The end of the hydrophilic segment is connected to the hydrophobic segment by ring-opening polymerization, and the reaction equ...

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Abstract

The invention relates to an antineoplastic nanometer heat sensitive target medicinal carrier used combined with chemical therapy and heat therapy, wherein the nano heat-sensitive targeting medicinal carrier employs amphiphilic segmented copolymer micelle, the hydrophobic fragments form inner cores, the hydrophilic fragments form outer-shells, the outer-shells surround the inner cores. the hydrophilic fragments comprise heat-sensitive polymers with a low critical solution temperature at 37-42 deg. C, the hydrophobic fragments comprise polylactic acid. The invention can avoid the injury to normal human tissue cells by chemotherapy medicaments.

Description

technical field [0001] The invention relates to a drug carrier, in particular to an anti-tumor nanometer heat-sensitive targeting drug carrier combined with chemotherapy and hyperthermia. Background technique [0002] At present, one of the traditional methods for treating tumors is chemotherapy, which lacks specificity to tumors, and its toxic and side effects limit its application. If the dosage is reduced, the toxic and side effects can be reduced, but the control effect on the tumor will be reduced. Hyperthermia is also a method of treating tumors. By heating the tumor tissue to 40-43°C, the growth of tumor cells will be hindered and death will be caused. Early hyperthermia was only applied to the treatment of superficial tumors. Later, due to the application of deep radiofrequency and whole-body hyperthermia equipment, hyperthermia was widely used. In clinical practice, hyperthermia is often used as an adjuvant therapy, and combined with chemotherapy and radiation the...

Claims

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Application Information

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IPC IPC(8): A61K47/30A61P35/00
Inventor 丁义涛杨觅刘宝瑞
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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