Antineoplastic nanometer heat sensitive target medicine carrier used combined with chemical therapy and heat therapy

Abstract

The invention relates to an antineoplastic nanometer heat sensitive target medicinal carrier used combined with chemical therapy and heat therapy, wherein the nano heat-sensitive targeting medicinal carrier employs amphiphilic segmented copolymer micelle, the hydrophobic fragments form inner cores, the hydrophilic fragments form outer-shells, the outer-shells surround the inner cores. the hydrophilic fragments comprise heat-sensitive polymers with a low critical solution temperature at 37-42 deg. C, the hydrophobic fragments comprise polylactic acid. The invention can avoid the injury to normal human tissue cells by chemotherapy medicaments.

Description

technical field [0001] The invention relates to a drug carrier, in particular to an anti-tumor nanometer heat-sensitive targeting drug carrier combined with chemotherapy and hyperthermia. Background technique [0002] At present, one of the traditional methods for treating tumors is chemotherapy, which lacks specificity to tumors, and its toxic and side effects limit its application. If the dosage is reduced, the toxic and side effects can be reduced, but the control effect on the tumor will be reduced. Hyperthermia is also a method of treating tumors. By heating the tumor tissue to 40-43°C, the growth of tumor cells will be hindered and death will be caused. Early hyperthermia was only applied to the treatment of superficial tumors. Later, due to the application of deep radiofrequency and whole-body hyperthermia equipment, hyperthermia was widely used. In clinical practice, hyperthermia is often used as an adjuvant therapy, and combined with chemotherapy and radiation the...

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Problems solved by technology

However, the carrier constructed by this method needs to be combined with doxorubicin through chemical bonds. Not only is the synthesis itself difficult, it is difficult to popularize and apply ...

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