Stable topical drug delivery compositions
A composition, stable technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of inability to store or carry
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Embodiment 1
[0018] Stable insulin topical formulations are formulated by first preparing a base solution. The polyalkenylphosphatidylcholine material designated NAT8729 was obtained from Rhone-Poulenc and contained 80.6% PPC-enriched phosphatidylcholine and 4.9% lysophosphatidylcholine. NAT 8729 (45% w / w) was planed and added to a mixture of polyethylene glycol E200 (50% w / w) and polyethylene glycol E400 (5% w / w), both from Dow Corning . The substrate solution was then capped and mixed slowly with a special decomposition head impeller at 800 rpm and slightly heated. The temperature is not higher than 40°C. Typical mixing time is 5 hours. The final solution was a clear, viscous amber solution without precipitation or stratification.
[0019] To this base solution (97.25% w / w) was then mixed Dow Corning Fluid 190 (1.00% w / w) [a siliconized polyether comprising dimethyl, methyl(propylpolyoxyethyleneoxypropylene, ethyl ester) silicone]; Dow Corning silicone fluid (1.00% w / w) code 200-5 o...
Embodiment 2
[0024] A stable insulin composition is formulated by first preparing a matrix solution. Weigh polyethylene glycol E200 (PEG-200) (50% w / w) and add polyethylene glycol E400 (PEG-400) (5% w / w) to the same container to obtain the desired weight (Both provided by Dow Corning). PEG-200 and PEG-400 were slowly mixed (speed 1) at 38-40° C. with IKA model RW20 using a decomposition head impeller at 800 rpm to obtain a PEG-200 / PEG-400 solution. The PPC-rich phosphatidylcholine material designated NAT 8729 from Rhne-Poulenc contained 80.6% PPC-rich phosphatidylcholine and 4.9% lysophosphatidylcholine. Planed NAT 8729 (45% w / w) and added to the PEG-200 / PEG-400 solution, capped and mixed at a temperature not exceeding 40°C until a clear, viscous amber solution was obtained without precipitation or separation. layer appears. The mixing time is about 5 hours. An alternative mixture can be prepared by capping and mixing the above solution overnight without heat to give 95-96% yield. The...
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