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Red-yeast extract and preparation therefor

A technology of extract and red yeast rice, applied in the field of medicine, can solve the problems of increasing gastrointestinal absorption load, adverse reactions, low content of active substances, inconvenience to patients, etc., and achieve the effects of reducing gastrointestinal load and adverse reactions, increasing content and improving production efficiency.

Active Publication Date: 2006-03-08
云南永安制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low content of active substances, the dosage of the preparation is relatively large, which increases the gastrointestinal absorption load and adverse reactions, causing inconvenience to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Get 1290g of red yeast rice medicinal material, after being pulverized into powder, 165g of sieved powder is obtained for subsequent use, and 3375ml of ethanol with a concentration of 75% is added to 1125g of red yeast rice powder on the sieve, placed in a 60°C water bath for reflux extraction for 3 hours, filtered, and the filtrate is used for subsequent use; Add 2250ml of ethanol with a concentration of 75% to the filter residue, put it in a water bath at 80°C for reflux extraction for 2 hours, filter, combine the filtrate, concentrate and recover ethanol, and concentrate the remaining red yeast extract to a relative density of 1.25-1.30 (55-60°C). 165g of fine powder of red yeast rice raw material is added to the concentrated extract, stirred evenly, dried at 90°C, and crushed to obtain red yeast rice extract when the water content of the extract is less than 5%.

Embodiment 2

[0021] Take 1000g of red yeast Chinese medicine decoction pieces, grind them into powder, and get 130g of sieved powder for later use, add 4350ml of ethanol with a concentration of 50% to 870g of red yeast rice powder on the sieve, put it in a water bath at 90°C for reflux extraction for 4 hours, filter, concentrate and recover Ethanol, when the remaining red yeast extract is concentrated to a relative density of 1.1-1.4 (55-60°C), add 130g of fine powder of red yeast rice raw material to the concentrated extract, stir evenly, and dry at 50°C. When the water content of the extract When the content is less than 5%, it is pulverized to obtain the red yeast extract.

Embodiment 3

[0023] Take 1000g of red yeast Chinese herbal medicine, crush it into powder, add 2000ml of ethanol with a concentration of 60%, put it in a water bath at 40°C for reflux extraction for 2 hours, filter, and use the filtrate for later use; add 2000ml of ethanol with a concentration of 40% to the filter residue, put it in a water bath at 65°C Reflux for extraction for 3 hours, filter, and the filtrate for subsequent use; add 1000ml of ethanol with a concentration of 85% to the filter residue, place in a 70°C water bath for reflux extraction for 1 hour, filter, combine the filtrates, concentrate and reclaim ethanol, and concentrate the remaining red yeast extract to a relative density of At 1.1-1.4 (55-60°C), add 200g of edible starch into the concentrated extract, stir evenly, and dry at 70°C. When the moisture content of the extract is less than 5%, pulverize to obtain the red yeast rice extract.

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PUM

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Abstract

The present invention provides an ang-kak extract and its preparation. It is characterized by adopting the following steps: using solvent whose mass is 2-5 times that of ang-kak and concentration is 40-85%, making extraction for three times at 40-90deg.C, every time is 4 hr, filtering, combining extracts, concentrating at normal temperature to obtain concentrate whose relative desinty is 1.1-1.4 under the temperature with 55-60deg.C, adding solid powder whose added quantity is 10-20% of mass of raw material in the concentrate, uniformly mixing them, drying at 50-90deg.C to make its water content be less than 5% so as to obtain ang-kak extract.

Description

technical field [0001] The invention relates to a preparation method of a red yeast extract-natural statin, which belongs to the technical field of medicine. Background technique [0002] In 1979, Japanese scholars Endo et al. isolated the HMG-CoA reductase inhibitor Monacolin K from Monascus. In 1980, American researchers Alberts et al. isolated the substance Mevinolic acid with the same structure from Aspergillus terreus. The compound was transformed into Lovastatin (Mevinolin) and marketed under the trade name "Mevacor", and it was widely used, which promoted the research and development of statin drugs. After that, a variety of statin drugs were launched. The second generation of statins: Simvastatin (Simvastatin) was launched. At present, there are nearly 10 kinds of statin drugs on the market. The clinical application of nearly two decades shows that statin drugs have the characteristics of significant curative effect and good tolerance. Side effects such as rhabdomy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P3/06
Inventor 李朝晖
Owner 云南永安制药有限公司
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