Red-yeast extract and preparation therefor

Abstract

The present invention provides an ang-kak extract and its preparation. It is characterized by adopting the following steps: using solvent whose mass is 2-5 times that of ang-kak and concentration is 40-85%, making extraction for three times at 40-90deg.C, every time is 4 hr, filtering, combining extracts, concentrating at normal temperature to obtain concentrate whose relative desinty is 1.1-1.4 under the temperature with 55-60deg.C, adding solid powder whose added quantity is 10-20% of mass of raw material in the concentrate, uniformly mixing them, drying at 50-90deg.C to make its water content be less than 5% so as to obtain ang-kak extract.

Description

technical field

[0001] The invention relates to a preparation method of a red yeast extract-natural statin, which belongs to the technical field of medicine. Background technique

[0002] In 1979, Japanese scholars Endo et al. isolated the HMG-CoA reductase inhibitor Monacolin K from Monascus. In 1980, American researchers Alberts et al. isolated the substance Mevinolic acid with the same structure from Aspergillus terreus. The compound was transformed into Lovastatin (Mevinolin) and marketed under the trade name "Mevacor", and it was widely used, which promoted the research and development of statin drugs. After that, a variety of statin drugs were launched. The second generation of statins: Simvastatin (Simvastatin) was launched. At present, there are nearly 10 kinds of statin drugs on the market. The clinical application of nearly two decades shows that statin drugs have the characteristics of significant curative effect and good tolerance. Side effects such as rhabdomy...