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Compound injection contg. alendronate sodium and vitamin D3

An alendronate sodium and injection technology, which is applied in the field of compound injection preparations containing alendronate sodium and vitamin D3, can solve the problem of no alendronate sodium and vitamin D3, etc., and achieve fast absorption and high absorption rate Effect

Inactive Publication Date: 2006-03-29
GUANGDONG XIANQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is no combined injection preparation of alendronate sodium and vitamin D3 in the prior art

Method used

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  • Compound injection contg. alendronate sodium and vitamin D3

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Prepare alendronate sodium vitamin D3 freeze-dried powder injection according to the following formula.

[0055] Specific formula:

[0056] Alendronate Sodium 70g

[0057] Vitamin D370mg (1400IU)

[0058] Hydroxypropyl-β-cyclodextrin 8g

[0059] Mannitol 100g

[0060] Absolute ethanol 10ml

[0061] Water for injection to 2500ml

[0062] A total of 1000 bottles of freeze-dried products were produced

[0063] Specific steps are as follows:

[0064] Preparation of liquid medicine:

[0065] (1) Weigh vitamin D3 according to the prescribed amount and dissolve it in 10ml of absolute ethanol for later use. Weigh hydroxypropyl-β-cyclodextrin according to the prescription, add 450ml of water for injection, stir fully, add the prepared vitamin D3 ethanol solution after it is completely dissolved, stir well and ultrasonicate for 15 minutes to make vitamin D3-cyclodextrin fine solution.

[0066] (2) Weigh alendronate sodium according to the prescription, add 2000ml of wat...

Embodiment 2

[0076] Prepare alendronate sodium vitamin D3 freeze-dried powder injection according to the following formula.

[0077] Specific formula:

[0078] Alendronate Sodium 35g

[0079] Vitamin D335mg (1400IU)

[0080] Hydroxypropyl-β-cyclodextrin 5g

[0081] Dextran 50g

[0082] Absolute ethanol 5ml

[0083] Water for injection to 2000ml

[0084] A total of 1000 bottles of freeze-dried products were produced

[0085] Specific steps are as follows:

[0086] Preparation of liquid medicine:

[0087] (1) Weigh vitamin D3 according to the prescribed amount and dissolve it in 5ml of absolute ethanol for later use. Weigh hydroxypropyl-β-cyclodextrin according to the prescription, add 300ml of water for injection, stir thoroughly, add the prepared vitamin D3 ethanol solution after it is completely dissolved, stir well and then ultrasonicate for 15 minutes to make vitamin D3-cyclodextrin fine solution.

[0088] (2) Weigh alendronate sodium according to the prescription, add 1500ml ...

Embodiment 3

[0096] Prepare alendronate sodium vitamin D3 injection according to the following formula.

[0097] Specific formula:

[0098] Alendronate Sodium 35g

[0099] Vitamin D335mg (1400IU)

[0100] Hydroxypropyl-β-cyclodextrin 5g

[0101] Absolute ethanol 5ml

[0102] Water for injection to 2000ml

[0103] A total of 1000 injections were prepared

[0104] Specific steps are as follows:

[0105] Preparation of liquid medicine:

[0106] (1) Weigh vitamin D3 according to the prescribed amount and dissolve it in 5ml of absolute ethanol for later use. Weigh hydroxypropyl-β-cyclodextrin according to the prescription, add 300ml of water for injection, stir thoroughly, add the prepared vitamin D3 ethanol solution after it is completely dissolved, stir well and then ultrasonicate for 15 minutes to make vitamin D3-cyclodextrin fine solution.

[0107] (2) Weigh alendronate sodium according to the prescription, add 1500ml of water for injection, and stir thoroughly at 70°C for 30 minut...

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Abstract

A compound injection for treating osteoporosis is prepared from sodium allenphosphonate, VD3, cosolvent, excipient and / or pH regulator.

Description

technical field [0001] The invention relates to a combined preparation of alendronate sodium and vitamin D3, more specifically, the invention relates to a compound injection preparation containing alendronate sodium and vitamin D3. Background technique [0002] As the world continues to age, the incidence of osteoporosis in the elderly is increasing. According to WHO regulations, the diagnostic criteria for osteoporosis is 2.5SD lower than the average BMD of young people. At present, there are about 200 million people in the world. Suffering from osteoporosis, its incidence rate ranks seventh among various common diseases. According to statistics, the incidence rate of osteoporosis in different age groups of the elderly: 21% for 50-60 years old, 58% for 60-70 years old, 100% for 70 years old and above. In my country, the number of people over 60 years old has accounted for 9% of the total population, and the number of new osteoporosis patients reaches 7 million every year. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/663A61K9/14A61K9/19A61P19/10A61K31/593
Inventor 刘春平李绍安康秋萍李云霞
Owner GUANGDONG XIANQIANG PHARMA
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