Small molecular inhibiting agent for coronavirus main proteinase, its preparation method and uses
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- TSINGHUA UNIV
- Publication Date
- 2006-04-26
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention provides a series of small molecule inhibitors designed based on the crystal structure of SARS coronavirus main protease, a preparation method and its application in the preparation of medicines for treating or preventing various coronavirus infections. Background technique
[0002] A new type of coronavirus has been identified as the culprit of severe acute respiratory syndrome (Severe Acute Respiratory Sydrome, referred to as SARS), and was named SARS coronavirus (referred to as SARS-CoV). SARS coronavirus belongs to "Nidovirales" order, "Coronaviridae" family, and "Coronavirus" genus in terms of species classification. It is a new variant in the coronavirus family, with a full length of 29,736bp (Urbani Strain). SARS is a severe infectious disease that poses a huge threat to human beings. Currently, there is no specific drug or vaccine on the market.
[0003] According to serological classification, the coronavirus family (Co...