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Delayed-release compounding Radix astragali gel skeleton tablets and its prepn. method

A technology of gel skeleton and astragalus, applied in the field of medicine, can solve problems such as inconvenient use, short half-life, frequent administration times, etc.

Inactive Publication Date: 2006-06-14
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Among them, the patent discloses drop pills and ordinary tablets prepared from the composition, but due to the short half-life of the water-soluble active ingredients in Radix Astragalus or Salvia Miltiorrhiza, common oral preparations face a series of problems, such as clinical administration Frequent doses, inconvenient use, poor patient compliance, etc.

Method used

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  • Delayed-release compounding Radix astragali gel skeleton tablets and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 Preparation of Compound Astragalus Ordinary Tablets

[0062] Take 86.5g of Astragalus, 21.3g of Salvia, 3.5g of Sanqi, and 20.6g of Jiangxiang; decoct the crushed Salvia and Sanqi in water twice, adding 7 times the amount of water each time, for 2 hours each time, and decocting together liquid, filtered, the filtrate was concentrated to 900ml, added 95% ethanol to make the alcohol concentration reach 70%, left to stand for 12 to 24 hours, filtered, recovered ethanol, and continued to concentrate into Danshen notoginseng extract;

[0063] Add water to decoct the crushed Astragalus membranaceus twice, add 6 times the amount of water each time, extract for 2 hours and 1 hour in turn, combine the filtrate, and when it is concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand 12-24 hours, filter, the filtrate recovers ethanol, and when it is concentrated to about 400ml, add 95% ethanol to make the alcohol concentration 80%...

Embodiment 2

[0065] Get 40.6g (30.0%) of Radix Astragali, 44.8g (33.1%) of Salvia Miltiorrhiza, 11.2g (8.3%) of Sanqi, 38.6g (28.6%) of Jiangxiang; Add 7 times the amount of water each time, 2 hours each time, combine the decoction, filter, concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, and recover ethanol , continue to concentrate into Danshen Sanqi extract;

[0066] Add water to decoct the crushed Astragalus membranaceus twice, add 6 times the amount of water each time, extract for 2 hours and 1 hour in turn, combine the filtrate, and when it is concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand After 12 to 24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml, add 95% ethanol to make the alcohol concentration 80%, let stand for 12 to 24 hours, filter, recover ethanol from the filtrate, and continue to concentrate into Astraga...

Embodiment 3

[0069] Take 86.5g (65.6%) of Radix Astragali, 21.3g (16.1%) of Salvia miltiorrhiza, 3.5g (2.7%) of Radix Notoginseng, 20.6g (15.6%) of Dalbergia radix; Add 7 times the amount of water each time, 2 hours each time, combine the decoction, filter, concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, and recover ethanol , continue to concentrate into Danshen Sanqi extract;

[0070] Add water to decoct the crushed Astragalus membranaceus twice, add 6 times the amount of water each time, extract for 2 hours and 1 hour in turn, combine the filtrate, and when it is concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand After 12 to 24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml, add 95% ethanol to make the alcohol concentration 80%, let stand for 12 to 24 hours, filter, recover ethanol from the filtrate, and continue to concent...

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Abstract

A slow-release gel skeleton tablet is prepared from astragalus root, red sage root, notoginseng, dalbergia wood and hydroxypropyl methylcellulose. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a sustained-release compound astragalus gel matrix tablet and a preparation method thereof. Background technique [0002] Astragalus membranaceus (Fisch.) Bge, var, monghlicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. Its main components are glycosides, polysaccharides, amino acids and trace elements. It has the effects of enhancing the body's immunity, diuresis, anti-aging, protecting the liver, lowering blood pressure, strengthening the heart, dilating coronary blood vessels and peripheral blood vessels of the whole body, and anti-bacteria. It is one of the commonly used traditional Chinese medicines in clinical practice. [0003] Motherland medicine believes that Astragalus can be used alone or in combination with other medicinal materials to achieve the desired clinical effect. After years of exploration, the inventor found tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/20A61P9/10
Inventor 郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD