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Delayed-release compounding tablets contg. red-rooted salvia gel skeleton, and its prepn. method

A technology of gel skeleton and Salvia miltiorrhiza, applied in the field of medicine, can solve the problems of frequent clinical administration, poor patient compliance, inconvenient use, etc.

Inactive Publication Date: 2006-06-14
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short half-life of the water-soluble active ingredients in Salvia miltiorrhiza, common oral preparations face a series of problems, such as frequent clinical administration, inconvenient use, poor patient compliance, etc.

Method used

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  • Delayed-release compounding tablets contg. red-rooted salvia gel skeleton, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take the following medicinal materials: Salvia miltiorrhiza 41.06g Notoginseng 8.03g, Borneol 0.46g;

[0051]Extraction of Danshen Sanqi medicinal materials: Take the coarsely crushed Danshen and Sanqi medicinal materials into the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, decoct After 1 hour, filter, discard the filter residue, and combine the filtrates. The filtrate was concentrated under reduced pressure until the volume (L) of the medicinal solution and the weight (Kg) of the medicinal material were 1:1, and 95% ethanol was slowly added to make the alcohol concentration of the medicinal solution 69-71%, and left to stand for 12 hours. Take the supernatant of the medicinal solution after alcohol precipitation, filter, recover ethanol from the filtrate, and concentrate it into an extract.

[0052] Preparation of gel matrix tablets: Take 5g of the ab...

Embodiment 2

[0054] Take the following medicinal materials: Danshen 31.12g Sanqi 9.21g borneol 0.50g

[0055] Extraction of Danshen Sanqi medicinal materials: Take the coarsely crushed Danshen and Sanqi medicinal materials into the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, decoct After 1 hour, filter, discard the filter residue, and combine the filtrates. The filtrate was concentrated under reduced pressure until the volume (L) of the medicinal solution and the weight (Kg) of the medicinal material were 1:1, and 95% ethanol was slowly added to make the alcohol concentration of the medicinal solution 69-71%, and left to stand for 12 hours. Take the supernatant of the medicinal solution after alcohol precipitation, filter, recover ethanol from the filtrate, and concentrate it into an extract.

[0056] Preparation of gel matrix tablets: Take 4.96g of the above-mentioned ex...

Embodiment 3

[0058] Take the following medicinal materials: Salvia miltiorrhiza 59.36g Sanqi 6.38g borneol 0.34g

[0059] Extraction of Danshen Sanqi medicinal materials: Take the coarsely crushed Danshen and Sanqi medicinal materials into the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, decoct After 1 hour, filter, discard the filter residue, and combine the filtrates. The filtrate was concentrated under reduced pressure until the volume (L) of the medicinal solution and the weight (Kg) of the medicinal material were 1:1, and 95% ethanol was slowly added to make the alcohol concentration of the medicinal solution 69-71%, and left to stand for 12 hours. Take the supernatant of the medicinal solution after alcohol precipitation, filter, recover ethanol from the filtrate, and concentrate it into an extract.

[0060] Preparation of gel matrix tablets: Take 5.12g of the above-...

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Abstract

A slow-release compound red sage root gel skeleton tablet is prepared from red sage root and notoginseng through extracting their active components, and mixing with hydroxypropyl methylcellulose (HPMC), lactose and magnesium stearate. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a sustained-release compound salvia miltiorrhiza gel matrix tablet and a preparation method thereof. Background technique [0002] Compound Danshen prescription has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is used to treat oppression in the chest and angina pectoris, and its main components are salvia miltiorrhiza, Sanqi and borneol. After years of clinical practice, people have gradually realized that in addition to the above-mentioned effects, compound salvia miltiorrhiza also has the effects of regulating blood lipids, anti-atherosclerosis (AS), and treating cerebral infarction. Since it came out in the 1970s, it has been well received by patients. [0003] The oral preparation of Compound Danshen has always been tablets. With the continuous development of pharmacy, there are...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P9/10
Inventor 郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD