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Medicinal composition and its preparation method

A technology for medicinal materials and extracts, applied in the field of gel matrix tablets of traditional Chinese medicine and their preparation, can solve the problems of inconvenient use, frequent administration times, poor patient compliance and the like

Inactive Publication Date: 2011-01-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the common preparations, the active ingredients therein face a series of problems, such as frequent clinical administration, inconvenient use, poor patient compliance, etc.

Method used

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  • Medicinal composition and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Take the following medicinal materials: Angelica 80g, Chuanxiong 80g, Paeoniae Alba 80g, Rehmannia glutinosa 80g, Uncle Teng 120g, Caulis Spatholobus 120g, Prunella vulgaris 120g, Cassia seed 120g, mother-of-pearl 120g, Yuanhu 70g, Asarum 10g;

[0056] Extraction of Radix Paeoniae Alba: Take 80g of Radix Paeoniae Alba, crush and sieve, add water and ultrasonically extract twice, the volume of water added for the first time is 10 times the amount of crude drug, ultrasonic frequency is 5MHz, time is 50min, and the crude drug is extracted for the second time 8 times the amount, the ultrasonic frequency is 5Mhz, and the time is 40min, the extracts are combined and concentrated to obtain the Radix Paeoniae Alba extract.

[0057] Extraction of other medicinal materials: Mix the above-mentioned other medicinal materials evenly, add water to extract twice, add water for the first time 8 times the amount of crude drug, extraction time is 2 hours, the second time is 6 times the am...

Embodiment 2

[0060] Take the following medicinal materials: Angelica 80g, Chuanxiong 80g, Paeoniae Alba 80g, Rehmannia glutinosa 80g, Uncle Teng 120g, Caulis Spatholobus 120g, Prunella vulgaris 120g, Cassia seed 120g, mother-of-pearl 120g, Yuanhu 70g, Asarum 10g;

[0061] Extraction of Radix Paeoniae Alba medicinal materials: take the crude drug of Radix Paeoniae Alba, crush it, pass through a 120 mesh sieve, add 80% ethanol to reflux and extract twice, the first time is 8 times the amount of crude drug, the second time is 5 times the amount of crude drug, extract 2 times respectively hour and 1 hour, combine the extracts, let stand overnight, filter, centrifuge (12000r / min) and filter, recover ethanol, and continue to concentrate to obtain the Radix Paeoniae Alba extract.

[0062] Extraction of other medicinal materials: Mix the above-mentioned other medicinal materials evenly, add water to extract twice, add water for the first time 8 times the amount of crude drug, extraction time is 2 h...

Embodiment 3

[0065] Take the following medicinal materials: Angelica 67.5g, Chuanxiong 67.5g, Paeoniae Alba 54g, Rehmannia glutinosa 54g, Uncle Teng 135g, Spatholobus 135g, Prunella vulgaris 135g, Cassia 135g, mother-of-pearl 135g, Yuanhu 67.5g, Asarum 14.5g;

[0066] Extraction of Rhizoma Chuanxiong: Take 67.5g of Rhizoma Chuanxiong, extract 3 times with 8 times 70% ethanol under reflux, the first and second time are 2 hours, the third time is 1.5 hours, combine the extracts, filter, recover ethanol, continue Concentrate to get Chuanxiong extract.

[0067] Extraction of other medicinal materials: Mix the above-mentioned other medicinal materials evenly, add water to extract twice, add water for the first time 8 times the amount of crude drug, extraction time is 2 hours, the second time is 6 times the amount of crude drug, extraction time is 1.5 hours, and combine the extracts , concentrated to a relative density of 1.10 (W / W), to obtain medicinal material extracts.

[0068] Preparation o...

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Abstract

A Chinese medicine in the form of gel skeleton tablet is prepared from white peony root, Chuan-xiong rhizome, Chinese angelica root and hydroxypropyl methylcellulose. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine gel matrix tablet and a preparation method thereof. Background technique [0002] The analgesic effect of Paeoniae Alba was first seen in "The Classic", which is said to "maintain evil abdominal pain... relieve pain". Modern pharmacological studies have also confirmed that intramuscular injection of total glucosides of paeony contained in white peony in mice has a dose-dependent analgesic effect, and peony bitter also has obvious analgesic effect. In addition, Radix Paeoniae Alba has various pharmacological effects, such as sedation, antispasmodic, anti-inflammatory, anti-stress, etc., so that it can be widely used in various pain diseases. [0003] Clinically, the inventor found that the prescription composed of Radix Paeoniae Alba, Angelica, Rhizoma Chuanxiong, etc. has a good effect on treating cerebral blood supply insufficiency. However, d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/804A61K9/20A61P29/00A61P25/04A61K35/56A61K35/618
Inventor 郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD